血清GRP水平与慢性自发性荨麻疹患者的疾病活动程度及瘙痒的关系

发布时间：2018-08-11 21:30

【摘要】：目的:本研究的目的是为了评估慢性自发性荨麻疹(CSU)患者血清中GRP的水平与疾病的活动程度及瘙痒程度的相关性。方法:连续收集2016年6月至2016年12月就诊于山大一院皮肤科的慢性自发性荨麻疹患者61例。随机抽取同期在我院健康体检人群59例。所有患者符合纳入和排除标准。根据UAS7表评估患者的活动程度,VAS评估患者的瘙痒程度,并通过CU-Q2oL表评估患者的生活质量,采用ELISA法检测所有标本中GRP含量,并通过SPSS 22.0软件进行统计分析,得到CSU患者血清中GRP水平与疾病活动程度以及瘙痒的相关性。结果:CSU患者血清中GRP水平为16.30±10.79pg/ml,健康对照组为8.41±1.89pg/ml,CSU患者GRP水平高于健康对照组(P0.05)。GRP的含量与患者病情活动程度得分呈正相关(r=0.361,P=0.004)。GRP含量与患者瘙痒程度得分呈正相关(r=0.344,P=0.007)。GRP的含量与患者生活质量得分呈正相关(r=0.562,P0.001)。每日瘙痒时间各组之间具有统计学差异(P0.05)。结论:GRP在CSU患者外周血中表达水平升高,并与活动程度得分、瘙痒得分、每日瘙痒持续时间和生活质量得分呈正相关,表明GRP可能与CSU的发病过程相关。
[Abstract]:Objective: to evaluate the correlation between the level of serum GRP and the degree of disease activity and pruritus in patients with chronic spontaneous urticaria (CSU). Methods: 61 patients with chronic spontaneous urticaria were collected from June 2016 to December 2016. A total of 59 healthy persons in our hospital were randomly selected at the same time. All patients meet the inclusion and exclusion criteria. The degree of pruritus was evaluated by UAS7, and the quality of life was evaluated by CU-Q2oL. The content of GRP in all samples was detected by ELISA method, and the results were analyzed by SPSS 22.0 software. The correlation between the level of serum GRP and the degree of disease activity and pruritus in patients with CSU was obtained. Results the level of GRP was 16.30 卤10.79pg / ml in the control group and 8.41 卤1.89pg / ml in the healthy control group. The level of GRP was positively correlated with the degree of disease activity (P 0.05). The level of GRP was positively correlated with the degree of pruritus score (r 0.344P0. 007) .GRP content was significantly higher than that in the healthy control group (P 0.05). There was a positive correlation between the level of GRP and the degree of pruritus (r 0.344P0. 007) .GRP content was positively correlated with the patient's disease activity score (r = 0.361P0. 004). There was a positive correlation between the quantity and the quality of life score (r = 0.562, P 0.001). The time of daily pruritus was statistically different among groups (P0.05). Conclusion the level of the expression of GRP in peripheral blood of patients with CSU was increased, and it was positively correlated with the score of activity degree, the score of pruritus, the duration of pruritus daily and the score of quality of life, indicating that GRP may be related to the pathogenesis of CSU.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.24

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