共聚焦激光扫描显微镜监测得肤宝治疗白癜风疗效及其在白斑性皮肤病中的应用
发布时间：2018-08-25 18:25
【摘要】：目的： 1.得肤宝外用治疗白癜风,与对照组达力士、二丙酸倍他米松临床疗效比较；通过共聚焦激光扫描显微镜监测3组疗效,判断白斑皮损治疗后基底层色素恢复程度及表皮其它变化。 2.利用CLSM对临床中常见的6种白斑性皮肤病的扫描图像特征初步探索。为临床白斑性皮肤病提供初步的诊断依据。 方法： 1.36例白癜风患者白斑皮损随机分为3组分别给予得肤宝、达力士、二丙酸倍他米松,于3-6月治疗期后,根据白癜风常规临床疗效判定标准,对3组药物治疗前后疗效的评价。利用CLSM分别监测3组皮损随访间期及治疗后基底层色素变化程度及表皮变化,评价3组实际色素程度恢复的差异及其它变化,从而发现白癜风临床与CLSM扫描病情恢复的差异。 2.利用CLSM分别观察132例白斑患者的皮损,记录基底层色素等级,及真表皮结构特点,初步判定贫血痣、白癜风、无色素痣、炎症后色素减退、花斑癣、白色糠疹的CLSM扫描图像特征及图像差异。 结果： 1. 3组临床疗效比较：3、6月治疗期后,得肤宝(A组)有效率均高于达力士(B组)、二丙酸倍他米松(C组),A组与B、C组相比有效率也具有统计学差异。而B组和C组有效率无明显统计学差异。6月治疗期后3组白癜风皮损不同部位临床有效率差别无统计学意义。A组治疗白癜风进展期和稳定期有效率有统计学差异,而B、C组无明显差异。3组不良反应无统计学差异。CLSM监测治疗后3组色素恢复等级、树枝状黑色素细胞存在与否、以及细胞水肿存在与否均有明显统计学差异。 2.6种白斑性皮肤病CLSM扫描图像特征：贫血痣基底层色素无明显减少；其余5类白斑性皮肤病均表现为色素不同程度减少,但其色素分布和色素减少程度各不相同。 结论： 1.得肤宝外用治疗白癜风临床疗效明显优于达力士和二丙酸倍他米松,CLSM观察得肤宝对于基底层色素恢复、树枝状黑色素细胞的生成等明显优于其它两组。 2.CLSM可用于初步分析和评价各型白斑性皮肤病的色素分布和脱失程度。
[Abstract]:Objective: 1. The clinical efficacy of Difubao in the treatment of vitiligo was compared with that of Dalix and betamethasone in control group, and the confocal laser scanning microscope was used to monitor the efficacy of the three groups. To judge the recovery degree of basal layer pigment and other changes of epidermis after the treatment of leukoplakia. 2. The scanning image features of 6 kinds of leukoplakia dermatoses were preliminarily explored by CLSM. To provide a preliminary diagnostic basis for clinical leukoplakia dermatosis. Methods: 1.Thirty six patients with vitiligo were randomly divided into 3 groups: Dafubo, Dalex and betamethasone dipropionate. To evaluate the curative effect of 3 groups before and after drug treatment. The changes of basal layer pigments and epidermis were monitored by CLSM during the follow-up period of skin lesions and after treatment, and the difference and other changes in the recovery of actual pigments in the three groups were evaluated. It was found that the difference between clinical and CLSM scan in patients with vitiligo was 2. 2. CLSM was used to observe the skin lesions of 132 patients with leukoplakia, to record the pigment grade of basal layer and the structure of true epidermis, and to determine the anaemic nevus, vitiligo, non-pigmented nevus, postinflammatory hypopigmentation, tinea versicolor. Features and differences of CLSM scan images of white pityriasis. Results: 1. The effective rate of dipropionate in group A was higher than that in group B, and the effective rate of betamethasone dipropionate in group A was significantly higher than that in group B after 6 months of treatment. The effective rate of betamethasone dipropionate in group A was also significantly higher than that in group B. But there was no significant difference in the effective rate between group B and group C. there was no significant difference in the clinical effective rate of different parts of vitiligo skin lesions in three groups after 6 months of treatment. The effective rate of group A in the progressive and stable stage of vitiligo was significantly different. However, there was no significant difference in adverse reactions between group 3 and group C. CLSM was used to monitor the grade of pigment recovery and the existence of dendritic melanocytes in the three groups after treatment. There were significant differences in the presence or absence of cell edema. The features of CLSM images of 2. 6 kinds of leukoplakia dermatoses were as follows: the pigments of basal layer of anaemic nevus did not decrease obviously, and the other 5 kinds of leukoplakia dermatoses showed decreased pigments in varying degrees. But its pigment distribution and pigment decrease degree are different. Conclusion: 1. The clinical efficacy of defubao in the treatment of vitiligo was significantly better than that of dalexin and betamethasone dipropionate CLSM in the restoration of basal layer pigment. The formation of dendritic melanocytes was superior to that of the other two groups, and 2.CLSM could be used to analyze and evaluate the distribution and loss of pigment in various types of leukoplakia skin diseases.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.41
本文编号：2203729
[Abstract]:Objective: 1. The clinical efficacy of Difubao in the treatment of vitiligo was compared with that of Dalix and betamethasone in control group, and the confocal laser scanning microscope was used to monitor the efficacy of the three groups. To judge the recovery degree of basal layer pigment and other changes of epidermis after the treatment of leukoplakia. 2. The scanning image features of 6 kinds of leukoplakia dermatoses were preliminarily explored by CLSM. To provide a preliminary diagnostic basis for clinical leukoplakia dermatosis. Methods: 1.Thirty six patients with vitiligo were randomly divided into 3 groups: Dafubo, Dalex and betamethasone dipropionate. To evaluate the curative effect of 3 groups before and after drug treatment. The changes of basal layer pigments and epidermis were monitored by CLSM during the follow-up period of skin lesions and after treatment, and the difference and other changes in the recovery of actual pigments in the three groups were evaluated. It was found that the difference between clinical and CLSM scan in patients with vitiligo was 2. 2. CLSM was used to observe the skin lesions of 132 patients with leukoplakia, to record the pigment grade of basal layer and the structure of true epidermis, and to determine the anaemic nevus, vitiligo, non-pigmented nevus, postinflammatory hypopigmentation, tinea versicolor. Features and differences of CLSM scan images of white pityriasis. Results: 1. The effective rate of dipropionate in group A was higher than that in group B, and the effective rate of betamethasone dipropionate in group A was significantly higher than that in group B after 6 months of treatment. The effective rate of betamethasone dipropionate in group A was also significantly higher than that in group B. But there was no significant difference in the effective rate between group B and group C. there was no significant difference in the clinical effective rate of different parts of vitiligo skin lesions in three groups after 6 months of treatment. The effective rate of group A in the progressive and stable stage of vitiligo was significantly different. However, there was no significant difference in adverse reactions between group 3 and group C. CLSM was used to monitor the grade of pigment recovery and the existence of dendritic melanocytes in the three groups after treatment. There were significant differences in the presence or absence of cell edema. The features of CLSM images of 2. 6 kinds of leukoplakia dermatoses were as follows: the pigments of basal layer of anaemic nevus did not decrease obviously, and the other 5 kinds of leukoplakia dermatoses showed decreased pigments in varying degrees. But its pigment distribution and pigment decrease degree are different. Conclusion: 1. The clinical efficacy of defubao in the treatment of vitiligo was significantly better than that of dalexin and betamethasone dipropionate CLSM in the restoration of basal layer pigment. The formation of dendritic melanocytes was superior to that of the other two groups, and 2.CLSM could be used to analyze and evaluate the distribution and loss of pigment in various types of leukoplakia skin diseases.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.41
【参考文献】
相关期刊论文 前7条
1 何萍秀;万川;罗来华;薛玮;;汗孔角化症的皮肤CT特征初探[J];南昌大学学报(医学版);2010年05期
2 刘栋,朱文元,谭城;皮质类固醇对培养Cloudman S91黑素瘤细胞株黑素合成的影响[J];临床皮肤科杂志;2003年01期
3 祁怀山,李志刚;他卡西醇软膏联合窄谱中波紫外线治疗白癜风临床疗效观察[J];临床皮肤科杂志;2004年10期
4 刘建东;张国强;;白癜风治疗的新进展[J];实用医学杂志;2008年07期
5 李泓馨;张选棉;高天文;;“皮肤CT”——皮肤病诊断的新手段[J];中国皮肤性病学杂志;2007年07期
6 金永红;许爱娥;相文忠;樊奇敏;宋秀祖;;白癜风自体表皮移植联合NB-UVB疗效及共聚焦激光扫描显微镜观察[J];中国皮肤性病学杂志;2010年02期
7 梁淑静;徐丽敏;肖尹;纪华安;;疣状表皮发育不良的共聚焦激光扫描显微镜下表现[J];中国皮肤性病学杂志;2011年03期
相关硕士学位论文 前2条
1 李欢;共聚焦激光扫描显微镜检测银屑病皮损的临床意义研究[D];天津医科大学;2008年
2 孙兆伟;共聚焦激光扫描显微镜在表皮增生性疾病诊断和评估治疗疗效的应用[D];天津医科大学;2010年
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