中毒性表皮坏死松解型药疹13例临床分析

发布时间：2018-08-25 18:44

【摘要】：目的了解重症医学科收治的中毒性表皮坏死松解型药疹患者的临床特征,为今后重症科医生和护士对该类患者尽早进行干预治疗和护理提供参考依据。方法收集本院重症医学科2009年3月-2014年3月收治的中毒性表皮坏死松解型药疹患者的临床资料,对其一般资料,如人口学数据、年龄、性别、职业、潜伏期、过敏史、可疑致敏药物、护理及治疗方法和转归等进行回顾性分析。结果 13例中毒性表皮坏死松解型药疹患者8例有既往史,别嘌醇所致药疹平均潜伏期明显较其他药物长,平均为13±7.6d。皮疹均为全身分布不规则的红斑及松弛性水疱或大疱且有不同程度的黏膜受累症状,实验室检查结果异常多。13例患者的住院时间为1~43d,平均17.31d。结论重症医学科的中毒性表皮坏死松解型药疹患者病情更凶险,病死率极高,针对病因尽早进行规范治疗和严格护理是决定患者预后与转归的关键因素。
[Abstract]:Objective to investigate the clinical features of toxic epidermal necrosis and release drug eruption treated in the Department of intensive Medicine (ICU), and to provide reference for the early intervention treatment and nursing care of these patients. Methods the clinical data of patients with toxic epidermal necrosis and release drug eruption admitted from March 2009 to March 2014 were collected, and the general data, such as demographic data, age, sex, occupation, incubation period, allergic history, were collected. The suspicious sensitizers, nursing and treatment methods and outcome were analyzed retrospectively. Results in 13 cases of toxic epidermal necrosis and release type drug rash, 8 cases had past history. The average latent period of allopurinol induced drug eruption was significantly longer than that of other drugs (13 卤7.6 days). The rash was characterized by erythema and loose blister or bullae with varying degrees of mucosal involvement. The hospitalization time of 13 patients with abnormal number of laboratory findings was 1: 43 days, with an average of 17. 31 days. Conclusion the patients with toxic epidermal necrosis and release drug rash in the department of intensive medicine are more dangerous and the mortality is very high. Early standardized treatment and strict nursing are the key factors to determine the prognosis and outcome of the patients.
【作者单位】：西安交通大学医学院第二附属医院重症医学科;
【分类号】：R758.25

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