儿童湿疹872例血清过敏原特异性IgE检测结果分析

发布时间：2018-08-26 11:01

【摘要】：目的:检测湿疹患儿常见的过敏原,寻找儿童湿疹可能的过敏促发因素,为其治疗及预防提供依据。方法:采用Mediwiss公司AllergyScreen Analytic GmbH过敏原检测系统,对872例湿疹患儿进行血清特异性IgE(specific IgE,sIgE)和总IgE检测,并在不同年龄组间进行比较。结果:872例湿疹患儿slgE阳性690例(79.13%),总IgE阳性709例(81.30%)。其中吸入性过敏原最常见的依次为户尘螨(34.60%)、点青霉(22.71%)、屋尘(16.28%)和狗毛皮屑(10.89%);食物性过敏原中,最常见的依次为牛奶(36.12%)、羊肉(22.94%)、鸡蛋白(20.07%)和牛肉(13.88%)。比较1岁组,1~3岁组和3岁组,户尘螨、屋尘、狗毛皮屑、点青霉、鸡蛋白、牛奶、羊肉和蟹的sIgE阳性率的差异有统计学意义(P0.05)。结论:户尘螨、点青霉和屋尘是湿疹患儿最主要的吸入性过敏原,牛奶、羊肉、鸡蛋白是湿疹患儿最常见的食物性过敏原。随年龄增大,吸入性过敏原逐步取代食物成为主要过敏原。血清sIgE检测为湿疹患儿提示了相关过敏原,可以针对性地回避相关过敏原。
[Abstract]:Objective: to detect the common allergens in children with eczema and to find out the possible anaphylaxis factors in children with eczema, and to provide evidence for the treatment and prevention of eczema. Methods: the serum specific IgE (specific IgE,sIgE and total IgE of 872 children with eczema were detected by AllergyScreen Analytic GmbH allergen detection system of Mediwiss Company, and were compared among different age groups. Results slgE was positive in 690 cases (79.13%) and total IgE in 709 cases (81.30%) in 872 cases of eczema. The most common allergens were dust mites (34.60%), penicillium (22.71%), house dust (16.28%) and dog hair dandruff (10.89%), the most common allergens were milk (36.12%), mutton (22.94%), egg white (20.07%) and beef (13.88%). There were significant differences in sIgE positive rate between 3 year old group and 3 year old group, house dust, dog hair dandruff, penicillium, egg white, milk, mutton and crab (P0.05). Conclusion: dust mites, penicillium and house dust are the most common food allergens in children with eczema. Milk, mutton and egg white are the most common food allergens in children with eczema. With age, inhaled allergens gradually replace foods as major allergens. The detection of serum sIgE indicated the related allergens in children with eczema and could avoid the related allergens.
【作者单位】：上海交通大学医学院附属上海儿童医学中心皮肤科;
【分类号】：R758.23

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