光动力治疗鲜红斑痣前后激光共聚焦显微镜的观察分析
发布时间：2018-08-27 08:21
【摘要】： 目的：本研究使用激光共聚焦显微镜对光动力治疗鲜红斑痣前后的疗效进行评价。 方法：本研究共选取34位临床上确诊为鲜红斑痣的患者,给予两次光动力治疗。第一次光动力治疗有约四分之一的患者为对照组,第二次光动力治疗不设对照组。每位患者分别于每次治疗前,治疗即刻后,治疗四天后,治疗8周后行共聚焦显微镜检查。 结果：未治疗的鲜红斑痣皮损处与同一患者正常皮肤比较,平均血管密度和平均血管直径均较大,有统计学差异。对照组第一次治疗前与第一次治疗后8周比较,平均血管密度和平均血管直径无统计学差异。治疗组第一次治疗前与第二次治疗后8周比较,平均血管密度有统计学差异,平均血管直径无统计学差异。结论：共聚焦显微镜是一种观察光动力治疗鲜红斑痣有效,无创的检测方法。
[Abstract]:Objective: to evaluate the efficacy of laser confocal microscopy before and after photodynamic treatment of nevus. Methods: in this study, 34 patients with nevus were treated twice with photodynamic therapy. About 1/4 of the patients in the first photodynamic therapy were in control group, and the second photodynamic therapy was not in the control group. Each patient was examined by confocal microscopy 8 weeks after each treatment, immediately after treatment, 4 days after treatment. Results: the mean blood vessel density and mean vessel diameter of the untreated nevus were larger than that of the normal skin of the same patient (P < 0.05). There was no significant difference in mean vessel density and mean vessel diameter between the control group and the control group before the first treatment and 8 weeks after the first treatment. In the treatment group, the mean vessel density was significantly different from that in the second treatment group at 8 weeks after the first treatment, and there was no significant difference in the mean vessel diameter between the first treatment group and the second treatment group. Conclusion: confocal microscope is an effective and non-invasive method for observing photodynamic therapy of nevus.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.51
本文编号：2206667
[Abstract]:Objective: to evaluate the efficacy of laser confocal microscopy before and after photodynamic treatment of nevus. Methods: in this study, 34 patients with nevus were treated twice with photodynamic therapy. About 1/4 of the patients in the first photodynamic therapy were in control group, and the second photodynamic therapy was not in the control group. Each patient was examined by confocal microscopy 8 weeks after each treatment, immediately after treatment, 4 days after treatment. Results: the mean blood vessel density and mean vessel diameter of the untreated nevus were larger than that of the normal skin of the same patient (P < 0.05). There was no significant difference in mean vessel density and mean vessel diameter between the control group and the control group before the first treatment and 8 weeks after the first treatment. In the treatment group, the mean vessel density was significantly different from that in the second treatment group at 8 weeks after the first treatment, and there was no significant difference in the mean vessel diameter between the first treatment group and the second treatment group. Conclusion: confocal microscope is an effective and non-invasive method for observing photodynamic therapy of nevus.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.51
【参考文献】
相关期刊论文 前3条
1 顾瑛;李峻亨;江亿平;粱洁;周萍;崔效杰;潘玉明;王开;;光动力学疗法选择性治疗鲜红斑痣的临床研究附40例报告[J];中国激光医学杂志;1992年01期
2 王开,顾瑛,李峻亨,梁洁,潘玉明,朱建国;光动力学疗法治疗中鲜红斑痣治疗区的反应[J];中国激光医学杂志;1999年02期
3 王维;林晓曦;;葡萄酒色斑的脉冲染料激光治疗现状及进展[J];组织工程与重建外科杂志;2008年06期
相关博士学位论文 前1条
1 李颖;在体共聚焦激光扫描显微镜在色素和肿瘤性皮肤病诊断中的应用研究[D];复旦大学;2008年
，本文编号：2206667
本文链接：https://www.wllwen.com/yixuelunwen/pifb/2206667.html
最近更新
教材专著
