血清DHEA-S、PRL水平与慢性荨麻疹关系的Meta分析
发布时间：2018-10-10 17:08
【摘要】：目的1.综合评价血清硫酸去氢表雄酮(Dehydroepiandrosterone-Sulfate,DHEA-S)水平与慢性荨麻疹(chronic urticaria,CU)的关系;2.综合评价血清催乳素(prolactin,PRL)水平与慢性荨麻疹的关系。方法1.应用主题词与自由词相结合的检索策略,计算机检索英文数据库Pub Med、Embase、Cochrane Library(2015年3期),中文数据库万方数据、CNKI、VIP、CBM,搜索有关血清DHEA-S水平与慢性荨麻疹关系的病例-对照研究;2.应用同样的方法,检索上述数据库,搜索有关血清PRL水平与慢性荨麻疹关系的病例-对照研究;3.检索时限均设置为各数据库从建库至2017年2月;4.2名研究人员独立进行文献筛选、资料提取、方法学质量评价;5.应用Rev Man 5.3软件包完成Meta分析、敏感性分析和发表偏倚风险评估。结果1.共纳入12篇相关文献,包括14个研究;2.满足血清DHEA-S水平与慢性荨麻疹关系的病例对照研究有10个;Meta分析结果显示慢性荨麻疹组较对照组DHEA-S水平低,差异有统计学意义[SMD=-0.94,95%CI(-1.09,-0.80),P0.00001];根据DHEA-S测量方法的不同进行亚组分析,均显示慢性荨麻疹组较对照组DHEA-S水平低,差异有统计学意义[电化学发光免疫分析技术(electrochemiluminescence immunoassay,ECLIA):SMD=-0.73,95%CI(-0.94,-0.52),P0.00001;酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA):SMD=-0.59,95%CI(-0.87,-0.31),P0.0001;酶免疫测定法(enzyme immunoassay,EIA):SMD=-2.33,95%CI(-1.92,-1.37),P0.00001];依据性别不同进行亚组分析,结果显示男性、女性亚组,病例组较对照组DHEA-S水平均低,且差异有统计学意义[女性:SMD=-0.99,95%CI(-1.20,-0.78),P0.00001;男性:SMD=-0.65,95%CI(-0.96,-0.33),P0.0001];依据女性生理时期不同,分为绝经期前和绝经期后两个亚组进行分析,结果显示仅绝经期前人群慢性荨麻疹患者DHEA-S水平较对照组低,差异有统计学意义,而绝经期后人群,未见明显差异[绝经期前:SMD=-1.17,95%CI(-1.40,-0.94),P0.00001;绝经期后:SMD=-0.13,95%CI(-0.62,0.37),P=0.62];3.满足血清PRL水平与慢性荨麻疹关系的病例对照研究有4个;Meta分析结果显示慢性荨麻疹组较对照组PRL水平高,差异有统计学意义[SMD=0.45,95%CI(0.21,0.70),P=0.0002];4.敏感性分析结果显示该结果稳定、可靠;5.漏斗图显示存在发表偏倚。结论1.血清低水平的DHEA-S可能与慢性荨麻疹的发生有关;2.在女性人群中,血清高水平的PRL可能与慢性荨麻疹的发生有关;3.受当前研究类型、质量和数量的限制,上述结论仍需进一步开展多中心大样本高质量的研究加以证实。
[Abstract]:Objective 1. To evaluate the relationship between serum dehydroepiandrosterone (Dehydroepiandrosterone-Sulfate,DHEA-S) level and chronic urticaria (chronic urticaria,CU). 2. To evaluate the relationship between serum prolactin (prolactin,PRL) level and chronic urticaria. Method 1. Using the search strategy of combining the subject word with the free word, the computer search English database Pub Med,Embase,Cochrane Library (2015 issue 3), the Chinese database Wanfang data, the CNKI,VIP,CBM, search about the serum DHEA-S level and the chronic urticaria relation case-control study; 2. The same method was used to search the above database and search the case-control study on the relationship between serum PRL level and chronic urticaria. The retrieval time limit was set for each database from the establishment of the database to February 2017; 4.2 researchers independently carried out literature screening, data extraction, methodological quality evaluation; 5. Meta analysis, sensitivity analysis and published bias risk assessment were performed with Rev Man 5.3 software package. Result 1. A total of 12 related articles, including 14 studies, were included. There were 10 case-control studies satisfying the relationship between serum DHEA-S level and chronic urticaria, and Meta analysis showed that the DHEA-S level of chronic urticaria group was lower than that of control group [SMD=-0.94,95%CI (-1.09- 0.80), P0.00001]. The levels of DHEA-S in chronic urticaria group were significantly lower than those in control group [electrochemiluminescence immunoassay (electrochemiluminescence immunoassay,ECLIA): SMD=-0.73,95%CI (-0.94- 0.52), P0.00001; enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay,ELISA): SMD=-0.59,95%CI (-0.87- 0.31), P0.0001; Enzyme-immunoassay (enzyme immunoassay,EIA): SMD=-2.33,95%CI (-1.92h-1.37), P0.00001]; The results showed that the level of DHEA-S in male, female subgroup and case group was lower than that in control group, and the difference was statistically significant [female: SMD=-0.99,95%CI (-1.20 -0.78), P0.00001; male: SMD=-0.65,95%CI (-0.96ng-0.33), P0.0001]; according to the physiological period of female, it was divided into two subgroups: premenopausal group and postmenopausal subgroup. The results showed that the level of DHEA-S in patients with chronic urticaria was significantly lower than that in the control group only before menopause, but there was no significant difference in postmenopausal population [pre-menopause: SMD=-1.17,95%CI (-1.40- 0.94), P0.00001; postmenopausal: SMD=-0.13,95%CI (-0.62n0.37), P0.62]; There were 4 case-control studies satisfying the relationship between serum PRL level and chronic urticaria, and Meta analysis showed that the PRL level of chronic urticaria group was higher than that of control group, and the difference was statistically significant [SMD=0.45,95%CI (0.21 卤0.70), P < 0.0002]; 4. The results of sensitivity analysis showed that the results were stable and reliable. The funnel diagram shows the existence of publication bias. Conclusion 1. The low level of serum DHEA-S may be related to the occurrence of chronic urticaria. In the female population, the high level of serum PRL may be associated with the occurrence of chronic urticaria; 3. Due to the limitations of current research types, quality and quantity, the above conclusions need to be confirmed by further multi-center, large sample and high quality studies.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.24
本文编号：2262598
[Abstract]:Objective 1. To evaluate the relationship between serum dehydroepiandrosterone (Dehydroepiandrosterone-Sulfate,DHEA-S) level and chronic urticaria (chronic urticaria,CU). 2. To evaluate the relationship between serum prolactin (prolactin,PRL) level and chronic urticaria. Method 1. Using the search strategy of combining the subject word with the free word, the computer search English database Pub Med,Embase,Cochrane Library (2015 issue 3), the Chinese database Wanfang data, the CNKI,VIP,CBM, search about the serum DHEA-S level and the chronic urticaria relation case-control study; 2. The same method was used to search the above database and search the case-control study on the relationship between serum PRL level and chronic urticaria. The retrieval time limit was set for each database from the establishment of the database to February 2017; 4.2 researchers independently carried out literature screening, data extraction, methodological quality evaluation; 5. Meta analysis, sensitivity analysis and published bias risk assessment were performed with Rev Man 5.3 software package. Result 1. A total of 12 related articles, including 14 studies, were included. There were 10 case-control studies satisfying the relationship between serum DHEA-S level and chronic urticaria, and Meta analysis showed that the DHEA-S level of chronic urticaria group was lower than that of control group [SMD=-0.94,95%CI (-1.09- 0.80), P0.00001]. The levels of DHEA-S in chronic urticaria group were significantly lower than those in control group [electrochemiluminescence immunoassay (electrochemiluminescence immunoassay,ECLIA): SMD=-0.73,95%CI (-0.94- 0.52), P0.00001; enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay,ELISA): SMD=-0.59,95%CI (-0.87- 0.31), P0.0001; Enzyme-immunoassay (enzyme immunoassay,EIA): SMD=-2.33,95%CI (-1.92h-1.37), P0.00001]; The results showed that the level of DHEA-S in male, female subgroup and case group was lower than that in control group, and the difference was statistically significant [female: SMD=-0.99,95%CI (-1.20 -0.78), P0.00001; male: SMD=-0.65,95%CI (-0.96ng-0.33), P0.0001]; according to the physiological period of female, it was divided into two subgroups: premenopausal group and postmenopausal subgroup. The results showed that the level of DHEA-S in patients with chronic urticaria was significantly lower than that in the control group only before menopause, but there was no significant difference in postmenopausal population [pre-menopause: SMD=-1.17,95%CI (-1.40- 0.94), P0.00001; postmenopausal: SMD=-0.13,95%CI (-0.62n0.37), P0.62]; There were 4 case-control studies satisfying the relationship between serum PRL level and chronic urticaria, and Meta analysis showed that the PRL level of chronic urticaria group was higher than that of control group, and the difference was statistically significant [SMD=0.45,95%CI (0.21 卤0.70), P < 0.0002]; 4. The results of sensitivity analysis showed that the results were stable and reliable. The funnel diagram shows the existence of publication bias. Conclusion 1. The low level of serum DHEA-S may be related to the occurrence of chronic urticaria. In the female population, the high level of serum PRL may be associated with the occurrence of chronic urticaria; 3. Due to the limitations of current research types, quality and quantity, the above conclusions need to be confirmed by further multi-center, large sample and high quality studies.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.24
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