TLR7、MyD88在皮肤肿瘤及癌前病变中的表达及意义

发布时间：2018-10-17 21:25

【摘要】：目的研究Toll样受体7(Toll-like receptor-7,TLR7)及髓样分化因子88(myeloid differentiation factor 88,MyD88)在光化性角化病(actinic keratosis,AK)、Bowen病(Bowen disease,BD)、皮肤鳞状细胞癌(cutaneous squamous cell carcinoma,SCC)组织中的表达及意义。方法免疫组化法检测22例AK、20例BD、23例SCC及15例正常皮肤组织中TLR7、MyD88的表达情况。结果 TLR7表达在细胞质中,其在SCC、BD、AK组及正常皮肤组中的阳性表达量用积分光密度值(integrated option density,IOD)计算,表达量分别为195.68±3.30、37.93±1.91、26.12±1.68、5.05±0.62,各组之间均有差异(P0.01)。MyD88表达在细胞质中,在SCC、BD、AK、正常皮肤中的IOD值分别为146.70±3.65、55.36±6.65、8.65±1.14、3.03±0.83,组间比较有差异性(P0.01),且TLR7及MyD88的表达呈正相关(r=0.973,P0.01)。结论 TLR7及MyD88表达增高可能在上述3种疾病的发生发展中起一定的作用,且两者可能有协同作用。
[Abstract]:Objective to study the expression and significance of Toll like receptor 7 (Toll-like receptor-7,TLR7) and myeloid differentiation factor 88 (MyD88) in the tissues of actinic keratosis,AK), Bowen's keratosis (Bowen disease,BD) and cutaneous squamous cell carcinoma (cutaneous squamous cell carcinoma,SCC). Methods Immunohistochemical method was used to detect the expression of TLR7,MyD88 in 22 cases of BD,23 and 15 cases of normal skin tissue. Results the positive expression of TLR7 in the cytoplasm of SCC,BD,AK group and normal skin group was calculated by integral optical density (integrated option density,IOD). The expression of TLR7 was 195.68 卤3.30 卤1.91 卤26.12 卤1.685.05 卤0.62respectively, and there was a difference between each group (P0.01). The expression of MyD88 was found in the cytoplasm. The IOD values in normal skin of SCC,BD,AK, were 146.70 卤3.65 卤6.65 卤6.65 卤1.14 卤3.03 卤0.83, respectively. There was a significant difference between the two groups (P0.01), and the expression of TLR7 and MyD88 were positively correlated (r = 0.973, P 0.01). Conclusion the increased expression of TLR7 and MyD88 may play a role in the occurrence and development of these three diseases, and they may have synergistic effects.
【作者单位】：重庆医科大学附属第一医院皮肤科;
【分类号】：R739.5

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