新疆维吾尔族寻常型银屑病中JAK1、STAT3蛋白的表达及意义

发布时间：2018-10-17 21:53

【摘要】：目的探讨JAK-STAT信号转导通路中JAK1和STAT3在新疆维吾尔族寻常型银屑病皮损组织中的表达及意义。方法采用免疫组化法检测45例维吾尔族寻常型银屑病皮损组织和21例维吾尔族正常表皮组织中JAK1和STAT3蛋白的表达,并复习相关文献。结果维吾尔族寻常型银屑病患者皮损组织中JAK1蛋白阳性率为77.78%,在维吾尔族正常表皮组织中的阳性率为28.57%;维吾尔族寻常型银屑病患者皮损组织中STAT3蛋白阳性率为86.67%,在维吾尔族正常表皮组织中的阳性率为23.81%,两组相比差异有统计学意义(P0.01)。结论维吾尔族寻常型银屑病发病可能与JAK-STAT信号转导通路中JAK1和STAT3蛋白异常表达相关。
[Abstract]:Objective to investigate the expression and significance of JAK1 and STAT3 in the lesions of psoriasis vulgaris in Xinjiang Uygur nationality. Methods Immunohistochemical method was used to detect the expression of JAK1 and STAT3 in 45 cases of psoriasis vulgaris and 21 cases of normal epidermis of Uygur. Results the positive rate of JAK1 protein in the lesions of Uygur patients with psoriasis vulgaris was 77.78, and the positive rate in the normal epidermis of Uygur was 28.577.The positive rate of STAT3 protein in the lesions of patients with psoriasis vulgaris was 86.67. The positive rate in Uygur normal epidermis tissue was 23.81, the difference between the two groups was statistically significant (P0.01). Conclusion the pathogenesis of psoriasis vulgaris in Uygur nationality may be related to the abnormal expression of JAK1 and STAT3 in JAK-STAT signal transduction pathway.
【作者单位】：新疆维吾尔自治区人民医院临床医学研究中心;新疆维吾尔自治区人民医院皮肤性病科;
【基金】：新疆维吾尔自治区自然科学基金(2015211C213)
【分类号】：R758.63

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