中西医结合治疗白癜风疗效的Meta分析

发布时间：2018-10-20 08:54

【摘要】：目的了解并评价中西医结合治疗白癜风的临床应用价值,为研治白癜风有效的治疗方法提供循证依据。方法检索国内外数据库,收集中西医结合治疗白癜风的相关文献,并选取符合条件的文献,运用Review Manager 5.1软件进行Meta分析。结果 (1)共纳入中文文献8篇,其中,A级文献5篇,B级文献3篇,共计患者851例,其中干预组514例,对照组337例;(2)采用随机效应模型进行Meta分析,结果显示中西医结合治疗白癜风比单纯西医治疗的有效率更高(RR=1.14,RR 95%CI=1.06~1.24),两组差异具有统计学意义(Z=3.41,P=0.0007),漏斗图基本对称,文献无发表偏倚;(3)治疗白癜风所采用的西药主要为他克莫司软膏或左旋咪唑片、微量元素和维生素三联剂,所采用的中药制剂主要有桃仁、当归、红花、黄芪、白蒺藜、川芎、赤芍、紫草、乌贼骨、紫河车、墨旱莲和补骨脂。结论中西医结合治疗可有效提高白癜风的疗效,使用频数较高的药物,为寻找白癜风有效的治疗方法提供了循证依据。
[Abstract]:Objective to understand and evaluate the clinical application value of integrated traditional Chinese and western medicine in the treatment of vitiligo, and to provide evidence-based basis for the effective treatment of vitiligo. Methods to search the database at home and abroad, collect the related literature on the treatment of vitiligo with integrated traditional Chinese and western medicine, and select the qualified literature, and use Review Manager 5.1 software to carry out Meta analysis. Results (1) eight Chinese literatures were included, of which 5 were of Grade A and 3 of Grade B, including 514 in intervention group and 337 in control group. (2) Meta analysis was performed with random effect model. The results showed that the effective rate of treatment of vitiligo by integrated traditional Chinese and western medicine was higher (RR=1.14,RR 95%CI=1.06~1.24) than that of western medicine alone. The difference between the two groups was statistically significant (ZH3.41PU 0.0007), the funnel graph was basically symmetrical. (3) the main western medicine used in the treatment of vitiligo was tacrolimus ointment or levamisole tablet, trace elements and vitamins, and the traditional Chinese medicine preparations were mainly peach kernel, Angelica sinensis, safflower, astragalus, Tribulus terrestris, Ligusticum chuanxiong. Radix Paeoniae rubra, purple grass, squid bone, purple river car, mauve and psoralen. Conclusion the combination of traditional Chinese and western medicine can effectively improve the curative effect of vitiligo and provide evidence-based basis for seeking effective treatment for vitiligo.
【作者单位】：海南省三亚市中医院皮肤科;
【分类号】：R758.41

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