口腔黏膜梭形细胞黑素瘤1例

发布时间：2018-11-14 18:13

【摘要】：患者女,63岁。左侧上颚部口腔黏膜褐色斑片3年,发生结节伴破溃6月余。皮肤科情况:左侧上颚部见一边界不清且不规则的淡褐色斑片,表面见一肤色结节。皮损组织病理示:黏膜上皮不规则增生,基底层黑素颗粒增多,真皮内交织排列的梭形细胞呈弥漫性增生,细胞核有异型改变,病变内散在色素颗粒。免疫组化检查示:Vimentin和S-100弥漫阳性,Ki-67约25%阳性。诊断:口腔黏膜梭形细胞黑素瘤。治疗:病变扩大手术切除,配合免疫疗法。
[Abstract]:The patient was 63 years old. The left maxillary oral mucosal brown patch occurred for 3 years, and the nodules with rupture occurred more than 6 months. Dermatology: an irregular pale brown patch on the left maxilla and a pigmented nodule on the surface. The histopathology of the lesions showed irregular proliferation of mucosal epithelium, increase of melanin granules in basal layer, diffuse proliferation of fusiform cells arranged in dermis, abnormal changes of nucleus and scattered pigment granules in the lesions. Immunohistochemical examination showed that Vimentin and S-100 were diffusely positive and Ki-67 was positive in about 25%. Diagnosis: oral mucosal spindle cell melanoma. Treatment: extensive surgical resection of lesions, combined with immunotherapy.
【作者单位】： 中国医学科学院北京协和医学院皮肤病医院;
【分类号】：R739.5

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