重症药疹99例继发真菌感染的危险因素分析

发布时间：2018-11-15 11:08

【摘要】：目的探讨重症药疹继发真菌感染的临床特点、易感因素以及预防措施。方法回顾性分析本院2004年1月-2012年12月诊治的99例重症药疹住院患者的临床资料,根据有无继发真菌感染分为感染组和未感染组。结果继发真菌感染21例(21.21%)。感染部位:以口腔为主55.17%(16/29),其次为泌尿道(13.79%,4/29);呼吸道、胃肠道及生殖道各3例(10.34%,3/29)。感染菌株:以白念珠菌为主14.29%(3/21)。两组患者的住院天数、激素最大用量及治疗时间、抗生素种类数、白细胞计数和血浆白蛋白水平的差异均有统计学意义(P均0.05)。结论重症药疹继发真菌感染可能与住院天数、激素最大用量及疗程、抗生素种类数、血白细胞计数、血浆白蛋白水平有关。其中抗生素种类数和血白细胞计数是其主要危险因素,而且应用过抗生素种类多少是继发真菌感染的独立危险因素。
[Abstract]:Objective to investigate the clinical characteristics, susceptible factors and preventive measures of fungal infection secondary to severe drug rash. Methods the clinical data of 99 hospitalized patients with severe drug rash from January 2004 to December 2012 were analyzed retrospectively. According to the secondary fungal infection, the patients were divided into infected group and non-infected group. Results 21 cases (21.21%) had secondary fungal infection. Infection site: oral cavity 55.17% (16 / 29), urinary tract (13.79) 4 / 29, respiratory tract, gastrointestinal tract and reproductive tract 3 cases (10.34 / 29). Infected strains were mainly Candida albicans 14.29% (3 / 21). There were significant differences in hospitalization days, maximum dosage of hormone and treatment time, number of antibiotics, white blood cell count and plasma albumin level between the two groups (all P 0.05). Conclusion severe drug rash secondary fungal infection may be related to the length of stay, the maximum dosage of hormone and course of treatment, the number of antibiotics, the white blood cell count and the level of plasma albumin. The number of antibiotics and white blood cell count were the main risk factors, and the number of antibiotics was the independent risk factor of secondary fungal infection.
【作者单位】：中国医科大学附属第一医院;
【分类号】：R758.25

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