天疱疮、类天疱疮患者生活质量评定及影响因素的研究
发布时间：2018-12-18 01:48
【摘要】： 目的 近年来大疱病患者的生活压力事件和生活质量已引起广泛关注。本研究评价天疱疮、类天疱疮患者生活质量,探讨影响其生活质量相关因素,了解医患双方对疾病的认知情况。 方法 2009年6月—2009年12月复旦大学附属华山医院病房和门诊经组织病理和免疫学确诊的自身免疫性大疱病84例,其中天疱疮组(n=44例)和类天疱疮组(n=40例),另设立寻常型银屑病为对照组(n=70例)。对大疱组患者进行疾病评估。经患者知情签字同意,给予世界卫生组织生活质量测定量表简表(WHOQOL-BREF)、皮肤病生活质量指数表(DLQI)、简明健康调查问卷(SF-36)和医患双方对疾病的认知情况问卷进行横断面调查。采用Stata10.0统计软件进行分析。采用t检验和Wilcoxon秩和检验。两变量间关联用Pearsonχ2检验。P0.05有统计学意义。 结果 WHOQOL-BREF比较,大疱组得分低于对照组,差异有统计学意义(P0.05)。在DLQI中,大疱组和对照组总分比较无统计学意义(P0.05)。在SF-36中,大疱组得分低于对照组,差异有统计学意义(P0.05)。以大疱病临床特征区分进行SF-36比较,类天疱疮组得分低于天疱疮组,皮损累及皮肤粘膜组得分低于累及皮肤组,疾病重度组得分低于轻、中度组,有合并(或并发)症组得分低于无合并(或并发)症组,差异均有统计学意义(P值均0.05)。合并(或并发)多种疾病组SF-36得分低于合并(或并发)一种疾病组,差异有统计学意义(P0.05)。医务人员对患者关于大疱病病情及激素副作用和服用激素期间应定期随访的检查项目告知率较高(90%),患者定期随访检查项目的依从性未知。 结论 1.天疱疮与类天疱疮患者较寻常型银屑病患者的生活质量低； 2.疾病类型、皮损分布、病情严重度和有无合并(或并发)症是影响大疱病患者生活质量的主要因素； 3.多种合并(或并发)症对大疱病患者生活质量的影响较一种合并(或并发)症者更为显著； 4.通过并发症的预防或干预可改善大疱性疾病患者的生活质量。
[Abstract]:Objective in recent years, stress events and quality of life in patients with bullous disease have attracted wide attention. In this study, the quality of life of pemphigoid and pemphigoid patients was evaluated. Methods from June 2009 to December 2009, 84 cases of autoimmune bullous disease diagnosed by histopathology and immunology, including 44 cases of pemphigus (n = 44) and 40 cases of pemphigoid (n = 40), were collected from ward and outpatient department of Huashan Hospital affiliated to Fudan University. Another 70 cases of psoriasis vulgaris were established as control group (n = 70). The patients in bullous group were evaluated. With the informed consent of the patient, give the World Health Organization quality of Life inventory (WHOQOL-BREF), skin disease quality of life index table (DLQI), The Concise Health Survey questionnaire (SF-36) and the questionnaire on the cognition of disease between doctors and patients were carried out cross-sectional. Stata10.0 statistical software was used to analyze. T test and Wilcoxon rank sum test were used. The correlation between two variables was tested by Pearson 蠂 2 test. P0.05 had statistical significance. Results compared with WHOQOL-BREF, the score of bullous group was lower than that of control group, the difference was statistically significant (P 0.05). In DLQI, the total scores of bullous group and control group were not statistically significant (P0.05). In SF-36, the score of bullous group was lower than that of control group, the difference was statistically significant (P0.05). Compared with the clinical features of bullous disease, the score of pemphigoid group was lower than that of pemphigoid group, the score of skin lesion group was lower than that of skin involvement group, and the score of severe disease group was lower than that of mild and moderate group. The scores of the patients with combined (or complicated) disease were lower than those of the patients without complication (P < 0.05). The scores of SF-36 in patients with multiple diseases were significantly lower than those in patients with multiple diseases (P0.05). The notification rate of patients with bullous disease and hormone side effects and should be regularly followed up during hormone use was higher (90%), and the compliance of patients with regular follow-up examination items was unknown. Conclusion 1. The quality of life in patients with pemphigus and pemphigoid was lower than that in patients with psoriasis vulgaris. The type of disease, the distribution of lesions, the severity of the disease and the presence or absence of complications were the main factors affecting the quality of life of patients with bullous disease. The effect of multiple complications on the quality of life in patients with bullous disease was more significant than that in patients with one type of combined disease (or complicated). 4. The quality of life of patients with bullous disease can be improved by prevention or intervention of complications.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.66
[Abstract]:Objective in recent years, stress events and quality of life in patients with bullous disease have attracted wide attention. In this study, the quality of life of pemphigoid and pemphigoid patients was evaluated. Methods from June 2009 to December 2009, 84 cases of autoimmune bullous disease diagnosed by histopathology and immunology, including 44 cases of pemphigus (n = 44) and 40 cases of pemphigoid (n = 40), were collected from ward and outpatient department of Huashan Hospital affiliated to Fudan University. Another 70 cases of psoriasis vulgaris were established as control group (n = 70). The patients in bullous group were evaluated. With the informed consent of the patient, give the World Health Organization quality of Life inventory (WHOQOL-BREF), skin disease quality of life index table (DLQI), The Concise Health Survey questionnaire (SF-36) and the questionnaire on the cognition of disease between doctors and patients were carried out cross-sectional. Stata10.0 statistical software was used to analyze. T test and Wilcoxon rank sum test were used. The correlation between two variables was tested by Pearson 蠂 2 test. P0.05 had statistical significance. Results compared with WHOQOL-BREF, the score of bullous group was lower than that of control group, the difference was statistically significant (P 0.05). In DLQI, the total scores of bullous group and control group were not statistically significant (P0.05). In SF-36, the score of bullous group was lower than that of control group, the difference was statistically significant (P0.05). Compared with the clinical features of bullous disease, the score of pemphigoid group was lower than that of pemphigoid group, the score of skin lesion group was lower than that of skin involvement group, and the score of severe disease group was lower than that of mild and moderate group. The scores of the patients with combined (or complicated) disease were lower than those of the patients without complication (P < 0.05). The scores of SF-36 in patients with multiple diseases were significantly lower than those in patients with multiple diseases (P0.05). The notification rate of patients with bullous disease and hormone side effects and should be regularly followed up during hormone use was higher (90%), and the compliance of patients with regular follow-up examination items was unknown. Conclusion 1. The quality of life in patients with pemphigus and pemphigoid was lower than that in patients with psoriasis vulgaris. The type of disease, the distribution of lesions, the severity of the disease and the presence or absence of complications were the main factors affecting the quality of life of patients with bullous disease. The effect of multiple complications on the quality of life in patients with bullous disease was more significant than that in patients with one type of combined disease (or complicated). 4. The quality of life of patients with bullous disease can be improved by prevention or intervention of complications.
【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.66
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