透明质酸凝胶联合丁酸氢化可的松乳膏治疗婴幼儿湿疹100例临床观察

发布时间：2018-12-26 09:50

【摘要】：目的观察透明质酸凝胶联合丁酸氢化可的松乳膏治疗婴幼儿湿疹的临床疗效和安全性。方法将入选的200例湿疹婴幼儿随机分为2组,各100例。全部患儿予丁酸氢化可的松乳膏皮损处外搽,2次/d,待皮疹减退时改为1次/d继续治疗7天后停药;治疗组患儿在外搽丁酸氢化可的松乳膏基础上加用透明质酸凝胶,待皮疹消退时单用透明质酸凝胶。比较两组患儿治疗前、治疗第28d时的皮疹恢复情况和皮肤水分含量。结果治疗第28天时,治疗组有效率、痊愈率和皮肤水分含量明显高于对照组,差异均有统计学意义(P均0.05)。治疗结束后2周时,治疗组2例复发,对照组7例复发,差异有统计学意义(P0.05)。结论透明质酸凝胶联合丁酸氢化可的松乳膏治疗婴幼儿湿疹疗效优于单用丁酸氢化可的松乳膏的疗效,能改善临床治疗效果,降低湿疹复发及减轻不良反应,值得临床推广使用。
[Abstract]:Objective to observe the efficacy and safety of hyaluronic acid gel combined with hydrocortisone butyrate cream in the treatment of infantile eczema. Methods 200 infants with eczema were randomly divided into two groups, 100 cases each. All the children were given hydrocortisone butyrate cream for 2 times a day. In the treatment group, hydrocortisone butyrate cream was added with hyaluronic acid gel on the basis of hydrocortisone butyrate cream, and only hyaluronic acid gel was used when the rash subsided. The rash recovery and skin moisture content were compared between the two groups before and after 28 days of treatment. Results on the 28th day, the effective rate, cure rate and skin moisture content in the treatment group were significantly higher than those in the control group (P 0.05). Two weeks after the end of treatment, the treatment group (2 cases) recurred, the control group (7 cases) recurred, the difference was statistically significant (P0.05). Conclusion Hyaluronic acid gel combined with hydrocortisone butyrate cream is superior to hydrocortisone butyrate cream in the treatment of infantile eczema. It is worth popularizing in clinic.
【作者单位】：杭州市第一人民医院皮肤科;
【分类号】：R758.23

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