天疱疮患者血浆催乳素和硫酸脱氢表雄酮水平变化的临床意义

发布时间：2019-01-02 12:47

【摘要】：目的探讨催乳素和硫酸脱氢表雄酮(DHEAS)在天疱疮患者外周血中的变化及临床意义。方法选取2013年2月至2016年2月衡水市哈励逊国际和平医院收治的84例天疱疮患者纳入天疱疮组,以该院同期体检健康的志愿者70例为对照组。采集空腹血标本,测定总催乳素、游离催乳素和DHEAS,天疱疮患者进行病情严重度分级,分析血浆总催乳素、游离催乳素和DHEAS变化及与天疱疮病情严重程度的关系。结果天疱疮组29例出现高催乳素血症(324mIU/L)。天疱疮组患者血浆总催乳素和游离催乳素水平均明显高于对照组,DHEAS水平明显低于对照组,差异均有统计学意义(P0.05)。天疱疮患者病情严重度与血浆总催乳素水平呈正相关(r=0.401,P=0.003),与DHEAS和游离催乳素水平均无明显相关性(r=-0.260、0.268,P=0.060、0.071)。结论天疱疮患者可出现高的催乳素水平和低的DHEAS水平,且与其病情严重度相关。血浆催乳素和DHEAS水平变化可作为天疱疮患者判断病情和指导治疗的重要指标。
[Abstract]:Objective to investigate the changes and clinical significance of prolactin and dehydroepiandrosterone (DHEAS) in peripheral blood of pemphigus patients. Methods Eighty-four patients with pemphigus from February 2013 to February 2016 were enrolled in the pemphigus group and 70 healthy volunteers were selected as the control group. Fasting blood samples were collected to determine the severity of pemphigus patients with total prolactin, free prolactin and DHEAS,. The changes of plasma total prolactin, free prolactin and DHEAS were analyzed and the relationship between total prolactin, free prolactin and pemphigus severity was analyzed. Results hyperprolactinemia (324mIU/L) was found in 29 cases in pemphigus group. The plasma levels of total prolactin and free prolactin in pemphigus group were significantly higher than those in control group, and the level of DHEAS was significantly lower than that in control group (P0.05). The severity of pemphigus was positively correlated with plasma total prolactin level (r = 0.401), but not with DHEAS and free prolactin levels (r = 0.260). Conclusion High prolactin level and low DHEAS level are associated with the severity of pemphigus. The changes of plasma prolactin and DHEAS levels can be used as an important index to judge the condition of pemphigus and guide the treatment.
【作者单位】：河北省衡水市哈励逊国际和平医院皮肤科;河北省衡水市第二人民医院;河北医科大学第四医院皮肤科;
【基金】：国家自然科学基金资助项目(81101179)
【分类号】：R758.66

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