口服氨甲环酸片辅助治疗黄褐斑的Meta分析

发布时间：2019-01-02 14:32

【摘要】：目的评价止血药氨甲环酸片治疗黄褐斑的疗效和安全性。方法计算机检索英文数据库PubMed,EBSCO,ISI Web of science,ovid,Science Direct,the Cochrane Library(2015年第12期)、CENTRAL,以及维普、中国知网(CNKI)、万方检索;时间从建库至2016年1月7日,查找关于氨甲环酸治疗黄褐斑的随机对照试验(RCT)研究,2位评价员独立筛选文献,提取资料和评价纳入研究的质量,使用Stata12.0软件进行Meta分析。结果共纳入RCT研究16篇,两组同时涉及有效率13篇,疗效评分5篇,报道不良反应情况14篇,复发情况4篇:(1)两组对比的疗效差异有统计学意义[OR=2.49,95%CI(1.39,4.46),P=0.002];(2)总有效率[r5=0.75,95%CI(0.69,0.82,P=0.000];总有效率[r6=0.93,95%CI(0.91,0.95,P=0.005];(3)疗程为8周时,氨甲环酸组的疗效评分低于对照组,差异有统计学意义[SMD=-1.23,95%CI(-1.38,-1.08),P=0.000];(4)4篇报道了不良反应情况,不良反应类型主要为胃肠道反应及月经量减少,3篇报道了复发的例数,1篇报道了复发的比率。结论氨甲环酸组治疗黄褐斑的疗效优于对照组;口服氨甲环酸片治疗黄褐斑安全性较为可靠,但存在复发情况。
[Abstract]:Objective to evaluate the efficacy and safety of the hemostatic tablets in the treatment of chloasma. Methods the English database PubMed,EBSCO,ISI Web of science,ovid,Science Direct,the Cochrane Library (No. 12 (2015) was searched by computer, and Weipu was searched by (CNKI), Wanfang. From the establishment of the database to January 7, 2016, we looked up a randomized controlled trial (RCT) study on the treatment of chloasma with carbamate. Two evaluators independently sifted the literature, extracted the data and evaluated the quality of the study. Use Stata12.0 software for Meta analysis. Results A total of 16 articles were included in the RCT study. The two groups involved 13 effective articles, 5 curative effect scores and 14 reports on adverse reactions. Recurrence: (1) the difference of curative effect between the two groups was statistically significant [OR=2.49,95%CI (1.39 卤4.46), P0. 002]; (2) the total effective rate [r _ (5) (0.75) ~ (95) CI (0.69 ~ 0.82) ~ (0.000), [r _ (6) 0.93 ~ (95) ~ (95) CI (0.911 ~ (0.95) P ~ (0.005)]; (3) when the course of treatment was 8 weeks, the score of therapeutic effect in the group of ammonia cyclitic acid was lower than that in the control group, and the difference was statistically significant [SMD=-1.23,95%CI (-1.38 卤1.08), P = 0.000]; (4) the adverse reactions were reported in 4 articles. The main types of adverse reactions were gastrointestinal reaction and menstrual volume decrease, 3 reports on the number of recurrence cases and 1 on the recurrence rate. Conclusion the efficacy of amethocyclylic acid group in the treatment of chloasma is better than that in the control group, and the safety of oral carbamate tablets in the treatment of chloasma is more reliable, but there is recurrence.
【作者单位】：重庆医科大学附属儿童医院药学部;重庆医科大学临床药学教研室;儿科学重庆市重点实验室;重庆医科大学附属儿童医院儿科研究所/儿童发育疾病研究教育部重点实验室;儿童发育重大疾病国家国际科技合作基地;重庆医科大学附属儿童医院皮肤科;
【分类号】：R758.42

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