p33ING1b和p53在银屑病和基底细胞癌中的表达及临床意义

发布时间：2019-02-23 23:28

【摘要】：目的:探讨肿瘤抑制因子p53和生长抑制因子p33ING1b在人类银屑病和基底细胞癌(basal cell carcinoma,BCC)中的表达情况及临床意义。方法 :采用免疫组织化学Envision方法检测p53和p33ING1b在36例寻常型银屑病皮损(银屑病组)、28例BCC皮损(BCC组)和14例正常表皮(正常对照组)中的蛋白表达。结果:p53在正常对照组、银屑病组和BCC组中表达递增,p33ING1b在3组中表达递减,组间比较差异均有显著性(均P0.05)。银屑病组和BCC组中,p53与p33ING1b之间均存在显著正相关(均P0.05)。结论:p53和p33ING1b协同作用于增生性皮肤病的局部皮损,是细胞异常增殖的重要机制之一。
[Abstract]:Objective: to investigate the expression and clinical significance of tumor suppressor p53 and growth inhibitor p33ING1b in human psoriasis and basal cell carcinoma (basal cell carcinoma,BCC). Methods: the expression of p53 and p33ING1b in 36 psoriatic lesions (psoriasis vulgaris group), 28 BCC lesions (BCC group) and 14 normal epidermis (normal control group) was detected by immunohistochemical Envision method. Results: the expression of p53 increased in normal control group, psoriatic group and BCC group, and the expression of p33ING1b decreased in three groups (P0.05). There was significant positive correlation between p53 and p33ING1b in psoriasis group and BCC group (P0.05). Conclusion: p53 and p33ING1b play a synergistic role in local skin lesions of proliferative dermatosis, which is one of the important mechanisms of abnormal cell proliferation.
【作者单位】：华中科技大学同济医学院附属协和医院皮肤科;湖北省中医院皮肤科;
【基金】：国家自然科学基金资助项目(编号:30972654,81271765,81171495) 湖北省自然科学基金资助项目(编号:2010CDB11001)
【分类号】：R758.63;R739.5

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