中等剂量糖皮质类固醇激素缓解带状疱疹疼痛及肿胀的疗效

发布时间：2019-02-24 08:44

【摘要】：目的探讨中等剂量糖皮质类固醇激素对缓解带状疱疹疼痛及肿胀的疗效。方法 62例带状疱疹患者按治疗方法分为观察组32例和对照组30例。两组均常规内服抗病毒、营养神经药物,观察组在此基础上给予泼尼松片,10 mg/次,3次/d,以7 d为1个疗程。比较两组止疱时间、结痂时间、疼痛消失时间、水肿消退及皮损痊愈时间及疼痛评分,并评价疗效。结果观察组总有效率为96.87%(31/32),与对照组86.67%(26/30)比较差异无统计学意义(χ2=2.12,P0.05);观察组痊愈率〔46.88%(15/32)〕明显高于对照组〔26.67%(8/30)〕(χ2=4.67,P0.05)。观察组止疱时间、结痂时间、疼痛消失时间、水肿消退及皮损痊愈时间均早于对照组(t=4.23、4.01、4.51、6.43、5.21,均P0.05)。观察组治疗后疼痛评分较治疗前显著下降(t=7.13,P0.05),且显著低于对照组(t=5.21,P0.05)。结论中等剂量糖皮质类固醇激素能有效缓解带状疱疹疼痛及局部水肿,促进皮损愈合。
[Abstract]:Objective to investigate the effect of middle dose glucocorticoid on relieving pain and swelling of herpes zoster. Methods 62 patients with herpes zoster were divided into observation group (n = 32) and control group (n = 30). Both groups were routinely given antiviral and nutritional neurodrugs, and the observation group was given prednisone tablets for 10 mg/, 3 times a day for 7 days as a course of treatment. The time of stopping blister, the time of scab formation, the time of pain disappearance, the time of edema receding, the healing time of skin lesion and the score of pain were compared between the two groups, and the curative effect was evaluated. Results the total effective rate in the observation group was 96.87% (31 / 32), and there was no significant difference between the observation group and the control group in 86.67% (26 / 30) (蠂 2 / 2.12 P 0.05). The recovery rate in the observation group (46.88%, 15 / 32) was significantly higher than that in the control group (26.67%, 8 / 30) (蠂 ~ 2 4.67%, P0.05). The time of stopping the blister, the time of scab formation, the time of the disappearance of pain, the time of edema receding and the healing time of the skin lesion in the observation group were earlier than those in the control group (t = 4.23 ~ 4.01 ~ 4.51 ~ 6.43 ~ 5.21, P0.05). The pain score of the observation group was significantly lower than that of the control group (P 0.05), and was significantly lower than that of the control group (P 0.05). Conclusion moderate dose of glucocorticoid can relieve herpes zoster pain and local edema and promote healing of lesions.
【作者单位】：贵阳市第四人民医院皮肤科;
【分类号】：R752.12

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