银屑病患者血清瘦素及Ghrelin的水平

发布时间：2019-02-24 11:16

【摘要】：目的探讨血清瘦素及生长激素促泌素受体的内源性配体Ghrelin水平与不同类型银屑病的发生及其病情的相关性。方法 50例银屑病患者及年龄、性别、体质指数(BMI)与之均衡的正常人对照30例,采用ELISA检测其血清瘦素及Ghrelin水平。结果银屑病患者血清瘦素水平(3.11±1.16)ng/mL较正常人对照组(2.33±0.82)ng/mL显著增高(P0.05):且与PASI评分呈正相关(r=0.915,P0.01),血清瘦素水平可见显著的性别差异(P0.01);银屑病患者血清Ghrelin水平(172.14±23.54)pg/mL较正常人对照组(143.67±15.76)pg/mL显著增高(P0.01),且与PASI评分呈负相关(r=-0.309,P0.05)。结论银屑病患者血清瘦素及Ghrelin水平升高,且与疾病严重程度有关联,提示瘦素和Ghrelin可能参与银屑病的发病机制。
[Abstract]:Objective to investigate the relationship between the levels of serum leptin and growth hormone receptor endogenous ligand Ghrelin and the occurrence of different types of psoriasis. Methods Serum leptin and Ghrelin levels were measured by ELISA in 50 psoriatic patients and 30 healthy controls with age, sex, body mass index (BMI). Results the serum leptin level in psoriatic patients (3.11 卤1.16) was significantly higher than that in normal controls (2.33 卤0.82) ng/mL (P0.05). There was a positive correlation between leptin and PASI score (r = 0.915, P 0.01). The serum leptin level showed significant gender difference (P0.01). The level of serum Ghrelin in psoriatic patients (172.14 卤23.54) pg/mL was significantly higher than that in the control group (143.67 卤15.76) pg/mL (P0.01), and was negatively correlated with PASI score (r-0.309) (P0.05). Conclusion Serum leptin and Ghrelin levels in patients with psoriasis were elevated and correlated with the severity of psoriasis, suggesting that leptin and Ghrelin might be involved in the pathogenesis of psoriasis.
【作者单位】：滨州医学院附属医院皮肤科;淄博市第三医院;滨州医学院附属医院输血科;
【分类号】：R758.63

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