疑似生殖器疱疹1312例HSV基因检测结果分析

发布时间：2019-02-25 21:28

【摘要】：目的了解海口地区疑似生殖器疱疹患者单纯疱疹病毒(HSV)感染情况。方法用核酸PCR-荧光探针法对本院1 312例疑似生殖器疱疹患者进行HSV-1/2型基因检测。结果 1 312例疑似生殖器疱疹患者中,HSV-1型阳性22例,阳性率1.68%(22/1 312),HSV-2型阳性621例,阳性率47.33%(621/1 312),单纯疱疹病毒阳性共643例,阳性率49.01%(643/1 312),无合并感染者。643例HSV阳性患者,有典型临床症状(溃疡、结痂、水疱等)426例,占66.25%;无症状217例,占33.75%。HSV-1型阳性率与HSV-2型阳性率比较,差异有统计学意义(P0.01)。643例单纯疱疹病毒感染者中,男465例,阳性率49.47%(465/940),女178例,阳性率47.85%(178/372),男女阳性率差异无统计学意义(P0.05)。结论海口地区疑似生殖器疱疹患者HSV阳性检出率高,感染有型别差异,以HSV-2为主。无症状HSV感染者占1/3,提示临床应重视对疑似生殖器疱疹患者进行HSV基因检测,避免误诊漏诊。HSV感染率无性别差异。
[Abstract]:Objective to investigate the infection of herpes simplex virus (HSV) in suspected genital herpes patients in Haikou area. Methods the HSV-1/ 2 gene was detected by nucleic acid PCR- fluorescence probe in 1 312 patients with suspected genital herpes in our hospital. Results among the 1 312 suspected genital herpes patients, 22 cases were positive for HSV- 1, the positive rate was 1.68% (22 / 1 312), the positive rate of HSV- 2 was 47.33% (621 / 1 312), the positive rate of HSV 1 was 1.68% (22 / 312), and the positive rate of HSV 2 was 47.33% (621 / 1 312). The positive rate was 49.01% (64.3%) and no co-infection. 643 cases of HSV positive patients had typical clinical symptoms (ulcer, scab, blisters, etc.), accounting for 66.25%. The positive rate of HSV-1 was significantly higher than that of HSV- 2 (P0.01). Among the 643 cases of herpes simplex virus infection, 465 cases were male, the positive rate was 49.47% (465 / 940). In 178 women, the positive rate was 47.85% (178 / 372). There was no significant difference in the positive rate between male and female (P0.05). Conclusion the positive rate of HSV in suspected genital herpes patients in Haikou area is high, and there are different types of infection, mainly HSV-2. Asymptomatic HSV infection accounted for 1 / 3, suggesting that clinical attention should be paid to the detection of HSV gene in suspected genital herpes patients, so as to avoid misdiagnosis and missed diagnosis. There is no gender difference in the infection rate of HSV.
【作者单位】：海南省皮肤性病防治中心;
【分类号】：R752.1

【参考文献】