寻常痤疮对患者生活质量和抑郁情绪影响的调查研究

发布时间：2019-02-27 16:37

【摘要】：目的了解寻常痤疮对患者生活质量和抑郁情绪的影响程度及相关因素,为综合、系统地治疗痤疮、提高患者的生活质量提供参考,同时也为制定有效的预防和干预措施提供科学依据。方法选取2010年10月至2011年6月就诊于中南大学湘雅三医院皮肤科门诊的寻常痤疮患者作为调查对象,采用现场发放问卷方式进行调查。采用皮肤病生活质量指数(DLQI)问卷评价过去一周内痤疮对患者生活质量的影响,Beck抑郁问卷(BID)评价痤疮患者的抑郁情绪严重程度,影响因素则通过自编问卷进行调查。使用Epidata3.1软件建立数据库,并采用SPSS16.0对资料进行统计分析,统计方法有统计描述、Spearman等级相关、Wilcoxon秩和检验,Kruskal-WallisH、多元回归分析、无序多分类logistic回归分析等。结果 1.共发放调查问卷295份,回收有效问卷287份。其中男性100例(34.8%),女性187例(65.2%)；年龄为18-40岁,平均(22.49±3.96)岁；寻常痤疮病情严重程度Ⅰ、Ⅱ、Ⅲ、Ⅳ级分别有165、56、38、28例,依次占57.5%、19.5%、13.2%、9.8%；病程为1个月～15年,平均(3.13±3.10)年。 2.287名寻常痤疮患者DLQI生活质量得分范围为0-28分,平均5.28分,患者生活质量的影响主要表现为疼痛或瘙痒、造成尴尬或自卑、影响社交休闲活动等。单因素分析显示年龄、病情严重程度、病程与患者的生活质量存在关系,而性别变量没有影响；多元回归分析结果表明,病情严重程度为患者生活质量的影响因素。 3.287名寻常痤疮患者的BDI抑郁总分为0～44分,平均8.55分。181例患者存在不同程度的抑郁(BDI总分≥5),检出率为63.1%,其中轻度抑郁129例(44.9%)、中度抑郁28例(9.8%)、重度抑郁24例(8.4%)。抑郁情绪主要表现为忧愁、悲观、对他人的兴趣减少(社会退缩)等。 4.单因素分析显示性别、痤疮病情严重程度、痤疮病程与患者的抑郁情绪存在关联,而年龄变量没有影响；无序多分类logistic回归分析结果显示性别、病情严重程度、痤疮病程与患者出现轻度和中重度抑郁情绪相关。 5.与寻常痤疮患者出现轻度,中重度抑郁相关的因素都为性别、病情严重程度、病程,女性患者相对于男性患者更易出现轻度和中重度抑郁(OR=3.62与OR=2.63),随着痤疮病情的加重,患者出现轻度和中重度抑郁的风险也相应增加(OR=2.31与OR=4.51),病程在1-3年和3年及以上的患者相对于病程不满1年的患者更容易出现轻度抑郁(OR=4.30与OR=7.44)。痤疮病程在3年及以上的患者相对于病程不满1年的患者更容易出现中重度抑郁(OR=3.60)。结论 1.寻常痤疮对患者的生活质量造成了明显的负面影响,主要表现为使患者出现疼痛或瘙痒症状、产生尴尬/自卑心理及影响其社交休闲活动等。 2.寻常痤疮病情越严重,患者的生活质量就越差。 3.寻常痤疮患者大部分存在不同程度的抑郁,主要表现为忧愁、悲观和社会退缩等心理。 4.患者病情越严重、病程越长及女性寻常痤疮患者更易出现不同程度的抑郁。
[Abstract]:Objective To study the effect of common ulcers on the quality of life and the mood of depression, and to provide a reference for the comprehensive and systematic treatment of ulcers, to improve the quality of life of patients, and to provide scientific basis for the development of effective prevention and intervention measures. Methods From October 2010 to June 2011, the patients from the Department of Dermatology of the Department of Dermatology of the Third Xiangya Hospital of Central South University were selected as the subject of the investigation, and the site distribution questionnaire was used for the adjustment. A. The effect of pressure sore on the quality of life of patients over the past week was evaluated by using the quality index (DLQI) of the skin disease. The Beck Depression Questionnaire (BID) was used to evaluate the severity of depression in the patients with ulcers, and the influence factors were adjusted by the self-designed questionnaire. The data were analyzed by using the Epidata3.1 software, and the data were analyzed statistically by using the SPSS16.0. The statistical methods include statistical description, Spearman rank correlation, Wilcoxon rank sum test, Kruskal-Wallis, multiple regression analysis, and multi-classification logistic regression analysis. And the like. Results 1. A total of 295 questionnaires were distributed and the effective question was recovered. There were 287 males (34.8%),187 (65.2%) females,18 to 40 years of age, (22.49 to 3.96) years of age,165,56,38 and 28 cases of common aphtha, 57.5%, 19.5%, 13.2%, and 9.8%, respectively; and the course of the disease was 1. Monthly-15 years, average (3.13-3) (10) The life quality score of DLQI in 2.287 patients with common aphtha was 0-28, with an average of 5.28 points. The quality of life of the patient was mainly manifested as pain or itch, resulting in embarrassment or inferiority. Social leisure activities, etc. The single factor analysis showed that the age, the severity of the condition, the course of the disease and the quality of life of the patient were not affected, and the sex variable had no effect; and the multiple regression analysis showed that the severity of the condition was the patient's life. The total score of BDI in 3.287 patients with common aphtha was 0 to 44, with an average of 8.55.181 patients had different degrees of depression (BDI total score of 5). The positive rate was 63.1%. Among them,129 (44.9%) of the patients with mild depression,28 (9.8%) of moderate depression, and severe depression. 24 (8.4%). The mood of depression is mainly in the form of sadness, pessimism, and interest in others. Decrease (social withdrawal) and so on.4. The single factor analysis showed that the severity of the condition of sex and aphtha, the duration of the sore and the depressive mood of the patient were associated, and the age variable had no effect; the result of the multi-classification logistic regression analysis of the disorder showing the severity of sex, the severity of the condition, the duration of the sore and the light of the patient 5. The factors related to mild and moderate-to-severe depression in patients with common ulcers were gender, severity of the disease, course of disease, and mild and moderate-to-severe depression (OR = 3.62 and OR = 2) in female patients with respect to male patients. 63) The risk of mild and moderate-to-severe depression was also associated with increased risk of mild and moderate-to-severe depression in patients (OR = 2.31 and OR = 4.51), and mild depression was more likely to occur in patients with a course of 1-3 years and more than 3 years and above (OR = 4.30 and OR = 7.44). The duration of the sore is more likely to occur in patients with less than 3 years and above with respect to patients with less than 1 year of disease Severe Depression (OR = 3.60). Conclusion 1. The quality of life of patients with common aphtha has a significant negative effect on the quality of life of the patient, which is mainly manifested in the occurrence of pain or itching symptoms in the patient, and the occurrence of depression. To find and influence their social and leisure activities. The more severe the condition of the ulcers, the worse the quality of life of the patient. The more severe the patient is, the more serious the illness is.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R758.733

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