重症药疹112例分析

发布时间：2019-04-02 02:19

【摘要】：目的探讨重症药疹的临床特点及治疗措施。方法对本科2011年4月-2016年3月收治的112例重症药疹患者进行回顾性分析。相关数据采用SPSS19.0软件进行统计学分析。结果平均开始激素量为(1.97±2.35)mg/kg;在治疗过程中有17例(15.18%)患者糖皮质激素加量,比不加量组平均激素总量大、平均住院日长、皮损好转时间长;糖皮质激素联合大剂量静脉注射用人免疫球蛋白治疗患者23例(20.54%),与单独使用糖皮质激素治疗组相比不能减少平均起始激素量和平均激素总量、不能缩短平均住院日及降低死亡率,但似乎可缩短皮损好转时间,预后好;经治疗痊愈51例(45.54%)、好转58例(51.79%)、死亡3例(2.68%)。结论重症药疹治疗要个体化,起始糖皮质激素用量应早期足量,早期联合大剂量静脉注射用人免疫球蛋白对危重患者的治疗似乎有帮助。
[Abstract]:Objective to investigate the clinical characteristics and treatment of severe drug eruption. Methods 112 patients with severe drug eruption admitted from April 2011 to March 2016 were retrospectively analyzed. The data were analyzed by SPSS19.0 software. Results the average initial hormone dose was (1.97 卤2.35) mg/kg; in 17 patients (15.18%), which was larger than that in the non-treated group, the average length of hospitalization was longer, and the time of skin lesion improvement was longer than that of the non-dosage group. Twenty-three patients (20.54%) were treated with glucocorticoid combined with high-dose human immunoglobulin. Compared with the treatment group treated with glucocorticoid alone, the average initial hormone amount and the average total hormone amount could not be reduced. It can not shorten the average hospital stay and reduce the mortality rate, but it seems to shorten the time for the improvement of skin lesions, and the prognosis is good. 51 cases (45.54%) were cured, 58 cases (51.79%) improved and 3 cases (2.68%) died. Conclusion the treatment of severe drug eruption should be individualized, the initial dosage of glucocorticoid should be sufficient early, and early combination with large dose intravenous injection of human immunoglobulin seems to be helpful in the treatment of critically ill patients.
【作者单位】：兰州大学第二医院;
【分类号】：R758.25

【参考文献】