中老年人大疱性类天疱疮合并内科疾病的临床特点

发布时间：2019-04-24 11:24

【摘要】：目的探讨中老年人大疱性类天疱疮(BP)合并临床疾病的特点。方法收集2011年3月至2013年9月在该院门诊就诊及住院的BP及湿疹患者的临床资料,对50例BP和49例湿疹患者的临床资料进行比较分析。结果 BP平均发病年龄为73.5岁,诊断前病程平均3.4个月;老年湿疹发病平均年龄70.3岁,诊断前病程平均2.7个月,老年BP合并内科疾病包括神经系统疾病19例(38%),其中有脑血管病17例(脑血栓、脑出血、脑梗死等)和帕金森病1例、痴呆1例;高血压7例(14%);糖尿病(DM)4例(8%);冠心病3例(6%);其他3例(6%)。老年湿疹伴发疾病包括:高血压20例(40.8%);DM 8例(16.3%);冠心病7例(14%);脑血管疾病5例(10.2%);其他7例(14%)。结论老年人BP合并神经系统疾病的情况较多见。二者合并出现的机制尚不清楚,免疫交叉反应或与年龄相关的某些变性退化的过程可能激发BP的发病。老年人湿疹则合并高血压、DM较多见,可能与体内代谢及内分泌变化及长期用降压药物及降糖药物有关。
[Abstract]:Objective to investigate the clinical features of pemphigoid (BP) in middle-aged and elderly people. Methods from March 2011 to September 2013, the clinical data of 50 cases of BP and 49 cases of eczema were analyzed. The clinical data of BP and eczema patients who were treated and hospitalized in the hospital from March 2011 to September 2013 were collected. Results the mean age of onset of BP was 73. 5 years, and the mean course of disease was 3. 4 months before diagnosis. The average age of onset of eczema was 70.3 years old and the course of disease was 2.7months before diagnosis. 19 cases (38%) of senile BP complicated with internal diseases included nervous system diseases, among them 17 cases had cerebrovascular disease (cerebral thrombosis, cerebral hemorrhage). Cerebral infarction, etc.) and Parkinson's disease (1 case), dementia (1 case); There were 7 cases of hypertension (14%), 4 cases of diabetic (DM) (8%), 3 cases of coronary heart disease (6%) and 3 cases of others (6%). The concomitant diseases of eczema in the elderly included hypertension in 20 cases (40.8%); DM in 8 cases (16.3%), coronary heart disease in 7 cases (14%), cerebrovascular diseases in 5 cases (10.2%) and others in 7 cases (14%). Conclusion BP complicated with nervous system diseases is more common in the elderly. The mechanism of the combination is not clear, and the immune cross-reaction or some age-related degeneration processes may stimulate the pathogenesis of BP. Eczema is associated with hypertension in the elderly, and DM is more common, which may be related to metabolic and endocrine changes in the body and long-term use of antihypertensive drugs and hypoglycemic drugs.
【作者单位】：鄂尔多斯市准格尔旗中蒙医院皮肤科;吉林大学第二医院;
【分类号】：R758.66

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