3例毛母细胞瘤临床病理分析

发布时间：2019-06-06 10:44

【摘要】：目的研究毛母细胞瘤(TB)的病理形态特征、诊断及鉴别诊断。方法回顾性分析3例TB临床病理特点、形态学及免疫表型特征,以及与多种疾病的鉴别诊断;另选择5例基底细胞癌行免疫表型检测并重点与TB相鉴别诊断。结果镜下可见,3例中肿瘤均位于皮下,不与表皮相连,单一的基底样细胞构成肿瘤主体,肿瘤周边细胞呈栅栏状排列。例1可见大小不等的囊腔及色素沉积,诊断为色素性TB;例2可见原始毛乳头样结构,诊断为TB;例3肿瘤中的基底样细胞核呈栅栏状排列,形成波纹状结构,诊断为波纹状TB。3例雄激素受体(AR)及2例B淋巴细胞2(Bcl-2)阴性表达,1例细胞角蛋白(CK)20散在阳性,3例CD10间质及毛乳头样结构阳性;5例基底细胞癌周边栅栏状排列的肿瘤细胞CD10阳性,4例AR阳性,3例Bcl-2阳性,5例CK20阴性。结论 TB是来源于毛囊生发上皮的良性肿瘤,完整切除预后良好,需重点与基底细胞癌相鉴别。
[Abstract]:Objective To study the pathological features, diagnosis and differential diagnosis of blastomas (TB). Methods The clinical and pathological features, morphology and immunophenotypic characteristics of 3 cases of basal cell carcinoma and the differential diagnosis of multiple diseases were analyzed retrospectively. Results Under the microscope,3 cases of the tumors were located under the skin and not connected with the epidermis, and the single basal-like cells formed the tumor main body, and the peripheral cells of the tumor were in a fence-like arrangement. example 1, the sac cavities and the pigment deposits of different sizes were found, and the diagnosis was pigmentary TB; in case 2, the original hair papilla-like structure was seen, and the diagnosis was TB; the substrate-like nucleus in the tumor of the third tumor was arranged in a fence shape to form a corrugated structure, 3 cases of androgen receptor (AR) and 2 cases of B-lymphocyte 2 (Bcl-2) negative expression,1 case of cytokeratin (CK)20 were positive,3 cases of CD10 were positive, and 3 cases of CD10 were positive. The CD10 positive,4 AR-positive,3-Bcl-2-positive and 5-CK20-negative were found in 5 cases of basal cell carcinoma. Conclusion TB is a benign tumor derived from hair follicle germinal epithelium.
【作者单位】：重庆市荣昌区人民医院病理科;武警重庆市总队医院病理科;
【分类号】：R739.5

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