性激素性脱发的临床分析

发布时间：2019-06-26 15:57

【摘要】：背景:雄激素性脱发是一种与雄激素及遗传相关的毛发疾病,引起头发脱落的因素并不完全清楚且目前疗效尚不满意。本文就雄激素性脱发的发病机制及治疗进行临床分析。目的:对雄激素性脱发的病因及发病机制、诊断及治疗进行分析,并评估联合用药的疗效。方法:本研究根据临床诊断标准纳入近330名雄激素性脱发患者进行临床观察研究,评价时间为6个月。并将受试者随机分为3组,每组给予不同的药物进行治疗。最后统计结果,运用卡方检验和t检验进行的统计学分析。结果:每年的8月和9月为雄激素性脱发的高发就诊时间。男性多于女性,40岁以下年轻患者明显多于高龄患者。患者多在开始脱发后的1-5年就医。从事脑力劳动者的发病率多于体力劳动者。对男性,联合米诺地尔、非那雄胺和异维A酸的疗效明显强于单一用药者(P0.05);对女性,联合米诺地尔、螺内酯和异维A酸的疗效强于单一用药者(P0.05)。异维A酸对男女头皮的油腻状况均有显著抑制作用(P0.05)。总结:雄激素性脱发是好发育于青春期男性及女性的毛发性疾病,它与雄激素及遗传有关,同时受精神心理状态的影响。联合用药对雄激素性脱发的治疗疗效更好。
[Abstract]:BACKGROUND: Androgen alopecia is a kind of hair disease related to androgen and inheritance, and the factors that cause the hair to fall off are not completely clear and the current curative effect is not satisfactory. This paper makes a clinical analysis of the pathogenesis and treatment of androgenic alopecia. Objective: To analyze the causes and pathogenesis, diagnosis and treatment of androgenic alopecia, and to evaluate the curative effect of combined use. Methods: According to the clinical diagnostic criteria, the clinical observation and evaluation of nearly 330 patients with androgen alopecia were carried out, and the evaluation time was 6 months. The subjects were randomly divided into three groups, each of which was treated with a different drug. The final statistical results were statistically analyzed using the chi-square test and t-test. Results: The high incidence of androgenic alopecia was the highest in August and September of each year. More men than women, younger patients under 40 years of age are significantly more than those of the elderly. The patient went to a doctor for 1 to 5 years after the onset of hair loss. The incidence of mental workers is more than that of physical workers. The results showed that the curative effect of the combination of minoxidil, finasteride and isovitamin A was stronger than that of single-use drug (P0.05), and the curative effect of the combination of minoxidil, spironolactone and isoproteic acid was stronger than that of single-use drug (P0.05). The effect of isoproteic acid on the oily condition of the scalp of male and female was significant (P <0.05). Summary: Androgen hair loss is a kind of hair disease which is well developed in the male and female of puberty. It is related to the androgen and the inheritance, and is affected by the mental state. The combination medicine has better curative effect on the treatment of androgenic alopecia.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.71

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