对比两种不同药物治疗老年原发性三叉神经痛患者的疗效和对睡眠质量的影响

发布时间：2017-12-27 20:18

本文关键词：对比两种不同药物治疗老年原发性三叉神经痛患者的疗效和对睡眠质量的影响　出处：《中国实用医药》2016年32期 　论文类型：期刊论文

【摘要】：目的观察拉莫三嗪与卡马西平治疗老年原发性三叉神经痛患者临床疗效以及对睡眠质量的影响。方法 72例原发性老年三叉神经痛患者,根据随机数字表法分为实验组和对照组,每组36例。实验组口服拉莫三嗪,对照组口服卡马西平。观察两组患者的临床治疗疗效、不良反应发生率以及睡眠质量评分。结果实验组显效23例、有效10例、无效3例;对照组显效14例、有效10例、无效12例,实验组的治疗总有效率为91.67%,显著高于对照组的66.67%,差异具有统计学意义(χ2=6.821,P0.05)。实验组患者治疗2个月后的睡眠质量总评分为(13.45±0.36)分,低于对照组的(16.64±0.42)分,差异具有统计学意义(t=-34.600,P0.01)。实验组不良反应发生率为16.67%,对照组为19.44%,两组比较差异无统计学意义(χ2=0.094,P=0.7590.05)。上述不良反应均未做特殊处理,后患者自行缓解。结论拉莫三嗪治疗老年原发性三叉神经痛近期疗效显著,安全性高,且有利于老年患者的睡眠,值得临床推广。
[Abstract]:Objective To observe the effects of lamotrigine and C Masi Bing in the treatment of elderly patients with primary trigeminal neuralgia patients clinical curative effect and the quality of sleep. Methods 72 patients with primary trigeminal neuralgia were divided into the experimental group and the control group according to the random digital table method, with 36 cases in each group. The experimental group was treated with lamotrigine, control group oral C Masi Bing. The clinical therapeutic effects, the incidence of adverse reactions and the quality of sleep in the two groups were observed. Results in the experimental group, 23 cases were markedly effective, 10 cases were effective, 3 cases were invalid. In the control group, 14 cases were markedly effective, 10 cases were effective, 12 cases were invalid, the total effective rate of the experimental group was 91.67%, significantly higher than that of the control group 66.67%, the difference was statistically significant (chi 2=6.821, P0.05). The total score of sleep quality in the experimental group after treatment for 2 months was (13.45 + 0.36), which was lower than that in the control group (16.64 + 0.42), and the difference was statistically significant (t=-34.600, P0.01). The incidence of adverse reactions was 16.67% in the experimental group and 19.44% in the control group. There was no significant difference between the two groups (x 2=0.094, P=0.7590.05). The afore-mentioned adverse reactions were not treated with special treatment, and the patients were relieved by themselves. Conclusion the short term curative effect of lamotrigine in the treatment of trigeminal neuralgia in elderly patients is significant, high safety, and is beneficial to elderly patients with sleep, is worthy of promotion.
【作者单位】：建昌县人民医院内一科;
【分类号】：R745.11
【正文快照】： 原发性三叉神经痛是一种以间歇痛为主要临床表现的较为常见的神经系统疾病,其疼痛的主要区域为第五对颅神经的分布区域[1]。一旦发生三叉神经痛这种强烈的不适感会严重影响患者的睡眠,而严重的睡眠障碍会导致抑郁现象的发生,目前临床上主要以药物治疗进行干预,来缓解患者病情[

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