GRASPS、SEDAN、HAT模型对非溶栓性脑梗死出血转化的预测价值

发布时间：2018-01-01 14:08

  本文关键词：GRASPS、SEDAN、HAT模型对非溶栓性脑梗死出血转化的预测价值　出处：《生物医学工程与临床》2016年06期 　论文类型：期刊论文

  更多相关文章： 急性脑梗死 出血转化 预测模型

【摘要】：目的探讨GRASPS、SEDAN、HAT模型在预测非溶栓性脑梗死出血转化中的临床应用价值。方法选择570例未经溶栓的急性脑梗死患者,其中男性375例,女性195例;年龄41~90岁,平均年龄68.41岁。根据头颅CT或MRI检查是否出血分为出血转化组和非出血转化组,其中出血转化组123例,非出血转化组447例。两组同时给予GRASPS、SEDAN、HAT模型评分。采用受试者工作特性曲线(ROC)获得HAT模型、SEDAN模型和GRASPS模型的灵敏度和特异度,计算曲线下面积。结果 HAT模型预测出血转化的灵敏度为63.4%,特异度为70.5%,曲线下面积0.717[95%可信区间(CI)0.661~0.772],最佳诊断界值为1.5。SEDAN模型预测出血转化的灵敏度为48.3%,特异度为51.7%,曲线下面积0.601(95%CI 0.546~0.656),最佳诊断界值为1.5。GRASPS模型预测出血转化的灵敏度为58.5%,特异度为63.1%,曲线下面积0.620(95%CI 0.564~0.676),最佳诊断界值为77.5。结论HAT、GRASPS、SEDAN模型用于非溶栓性脑梗死出血转化有一定的预测价值,但以HAT模型预测能力最强。
[Abstract]:Objective to evaluate the clinical value of grass PSV SEDANHAT model in predicting the transformation of non-thrombolytic cerebral infarction. Methods 570 patients with acute cerebral infarction without thrombolysis were selected. There were 375 males and 195 females; The average age was 68.41 years old. According to CT or MRI examination, the patients were divided into two groups: hemorrhage conversion group and non-bleeding conversion group, among which 123 cases were bleeding conversion group. There were 447 cases in the non-bleeding conversion group. The HAT model was obtained by using the operating characteristic curve (ROC) of the subjects in both groups, and the score of grass PSV SEDANHAT model was given at the same time. The sensitivity and specificity of SEDAN model and GRASPS model were calculated and the area under the curve was calculated. Results the sensitivity and specificity of HAT model for predicting hemorrhage transformation were 63.4 and 70.5% respectively. Area under curve 0.717. [The best diagnostic threshold was 1.5.SEDAN model. The sensitivity of predicting hemorrhage transformation was 48.3, and the specificity was 51.7%. The area under the curve was 0.601 / 95 / CI 0.546 / 0.656, and the best diagnostic threshold was 1.5.GRASPS model with a sensitivity of 58.5%. The specificity was 63.1, the area under the curve was 0.620 ~ 95CI 0.564and the best diagnostic threshold was 77.5.ConclusionHATA GRASPS. The SEDAN model has certain predictive value for the transformation of non-thrombolytic cerebral infarction, but the HAT model is the best.
【作者单位】： 广饶县人民医院神经内科;青岛市中心医院心内科;青岛大学附属医院神经内科;青岛大学附属医院心内科;
【分类号】：R743.33
【正文快照】： 作者单位:1.广饶县人民医院神经内科,山东东营257300;2.青岛市中心医院心内科,山东青岛266042;3.青岛大学附属医院a.神经内科;b.心内科,山东青岛266003脑梗死出血转化是指脑梗死后,梗死区域恢复血流灌注,导致继发性出血[1]。有报道急性脑梗死后自发出血转化的发生率为10%~40%[，

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