非酒精性Wernicke脑病临床特点及MRI表现

发布时间：2018-01-03 04:06

本文关键词：非酒精性Wernicke脑病临床特点及MRI表现　出处：《国际医学放射学杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的探讨非酒精性Wernicke脑病(WE)病人临床特点及MRI表现。方法回顾性分析经临床证实的10例非酒精性WE病人临床特点及MRI表现。结果胃肠道疾病所致反复呕吐、急性胰腺炎及妊娠剧烈呕吐为主要发病诱因。精神或意识改变为最常见临床表现。10例病人中仅1例为单发病灶,余9例均为多部位受累,病变部位包括双侧丘脑内侧及三脑室周围区(8例)、中脑导水管周围区(7例)、中脑顶盖(6例)、乳头体(4例)、四脑室底(4例)、小脑蚓部(1例)。所有病灶均于T2WI或T2FLAIR上呈对称性高信号。8例行DWI扫描,病灶呈高或稍高信号。1例行MRI增强检查,病灶呈轻度强化。4例于治疗后复查颅脑MRI,均见病灶缩小或消失。结论非酒精性WE的颅脑MRI表现具有特征性,结合病史及临床表现有助于做出早期诊断。
[Abstract]:Objective to investigate the nonalcoholic Wernicke encephalopathy (WE) and clinical features of MRI patients. Methods Retrospective analysis of the clinical features of 10 cases of MRI and non alcoholic WE patients showed clinically confirmed gastrointestinal diseases. The results caused by repeated vomiting, acute pancreatitis and severe pregnancy vomiting were the main predisposing factors. The most common spirit or consciousness change the clinical manifestations of.10 patients, only 1 cases were single lesions, 9 cases were multiple lesions, including the lesion area around the bilateral medial thalamus and three ventricle (8 cases), the area around the cerebral aqueduct (7 cases), mesencephalic tectum (6 cases), nipple body (4 cases), the end of the four ventricle (4 cases), cerebellar vermis (1 cases). All lesions were in the T2WI or T2FLAIR showed symmetrical high signal.8 underwent DWI scan, the lesions showed high or slightly high signal on.1 were enhanced MRI examination, lesions showed mild enhancement in.4 patients after treatment MRI scans, lesions were seen to shrink or disappear. Conclusion the MRI features of craniocerebral WE are characteristic, combined with the medical history and clinical manifestation, it is helpful to make early diagnosis.

【作者单位】：天津医科大学总医院放射科;
【基金】：国家自然科学基金面上项目(81271564) 卫计委公益性行业科研专项项目(201402019) 天津市自然科学基金重点项目(12JCZDJC23800)
【分类号】：R591.42;R741;R445.2
【正文快照】： Int J Med Radiol,2016,39(2):103-106Wernicke脑病(Wernicke’s encephalopathy,WE)是维生素B1缺乏引起的一种急性中枢神经系统代谢性脑病,临床上以意识或精神改变、眼部症状和小脑功能障碍“三联征”为主要表现。慢性酒精中毒是WE主要诱因,但胃肠外营养及营养不良等所致维生

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