左乙拉西坦添加治疗儿童额叶癫痫58例临床分析

发布时间：2018-01-08 17:12

本文关键词：左乙拉西坦添加治疗儿童额叶癫痫58例临床分析　出处：《中南药学》2016年12期 　论文类型：期刊论文

【摘要】：目的研究左乙拉西坦(LEV)添加治疗儿童额叶癫痫的疗效及安全性。方法采用自身对照研究,对58例确诊为儿童额叶癫痫且抗癫痫治疗疗效欠佳的患儿进行LEV添加治疗,对添加治疗前与添加治疗期间平均癫痫发作频率进行比较,观察LEV添加治疗儿童额叶癫痫的临床疗效,同时,对添加治疗LEV前2 h与随访期末2 h视频脑电图中发作间期痫样放电(IEA)数量进行比较,以明确LEV能否减少额叶癫痫患儿脑电图IEA,观察疗效及不良反应至少12个月。结果 LEV添加治疗3个月时临床总有效率达65.52%,无临床发作比例为29.31%,与添加治疗前比较差异具有统计学意义(P0.05),6个月及12个月疗效与近期疗效(3个月)相仿。LEV添加治疗12个月时脑电图改善率达60.34%,脑电图控制率为24.13%,与添加治疗前比较差异具有统计学意义(P0.05),1例患儿因服用LEV后出现神经质而停药,停药后症状消失。结论 LEV添加治疗儿童额叶癫痫有良好临床疗效,同时可减少额叶癫痫患儿脑电图IEA,且不良反应发生率低,对奥卡西平等抗癫痫药物疗效欠佳的儿童额叶癫痫患儿,LEV添加治疗可能是一种很好的选择。
[Abstract]:Objective to study the efficacy and safety of levoethiracetam plus Levol in the treatment of frontal lobe epilepsy in children. 58 children with frontal lobe epilepsy diagnosed as children with poor antiepileptic effect were treated with LEV plus therapy. The average frequency of epileptic seizures before and after addition therapy was compared. To observe the clinical efficacy of LEV in the treatment of frontal lobe epilepsy in children. At the same time, to compare the number of epileptiform discharges of interictal epileptiform discharges in the video EEG 2 hours before and 2 hours after the end of follow-up in the treatment of children with frontal lobe epilepsy. In order to determine whether LEV can reduce EEG in children with frontal lobe epilepsy, the curative effect and adverse reaction were observed for at least 12 months. Results the total clinical effective rate reached 65.52% when LEV was added for 3 months. The rate of no clinical attack was 29.31%, and the difference was statistically significant compared with that before treatment (P 0.05). The improvement rate of electroencephalogram (EEG) was 60.34 and the control rate of EEG was 24.13% at 12 months after 6 months and 12 months of treatment, which was similar to the short-term curative effect (3 months). The difference was statistically significant compared with that before addition therapy in one child who had developed neuroticism after taking LEV. Conclusion LEV supplementation has a good clinical effect on frontal lobe epilepsy in children, and can reduce the EEG of children with frontal lobe epilepsy, and the incidence of adverse reactions is low. It may be a good choice to treat children with frontal lobe epilepsy with O'Casey 's equal antiepileptic drugs.
【作者单位】：湖南省儿童医院神经一科;
【分类号】：R742.1
【正文快照】： 额叶癫痫是一组起源于额叶的具有特征性的癫痫综合征,额叶癫痫占各类部分性癫痫的20%~30%,儿童期额叶癫痫更常见[1],额叶癫痫是儿童时期最常见的部分性癫痫,部分儿童额叶癫痫抗癫痫治疗疗效欠佳。儿童正处在身心迅速发育的阶段,如果癫痫发作控制不良,易致惊厥性脑损伤,患儿的

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