丙戊酸钠注射液与左乙拉西坦联合对难治性癫痫持续状态的影响分析

发布时间：2018-01-08 19:31

本文关键词：丙戊酸钠注射液与左乙拉西坦联合对难治性癫痫持续状态的影响分析　出处：《海峡药学》2016年01期 　论文类型：期刊论文

【摘要】：目的探讨联合使用丙戊酸钠与左乙拉西坦的治疗方式对控制难治性癫痫持续状态的重要影响和意义。方法将我们医院2014年4月~2015年6月神经内科中具有难治性癫痫持续状态的患者72例作为本次治疗的研究对象;随机分为联合组,丙戊酸钠组和左乙拉西坦组,3组人数均为24名;对丙戊酸钠组的研究对象施行丙戊酸钠注射液治疗;左乙拉西坦组对该组研究对象予以左乙拉西坦片(UCB S.A.比利时,进口药品注册标准JX20070146)口服;联合组则采取的是注射丙戊酸钠的同时口服左乙拉西坦片。结果丙戊酸钠组总有效率为66.67%,左乙拉西坦组总有效率为62.5%,而两种药物联合治疗法的总有效率为91.67%,结果具有统计学意义(P0.05)。另一方面,从达到控制癫痫持续状态的时间来看,联合组的控制时间相对较短(41.64min),相对优于上述两组的药物生效时间。结论联合使用上述两种药物,对难治性癫痫持续状态的控制有更好的效果和影响。
[Abstract]:Objective to investigate the effect and significance of combined use of sodium valproate and levoethylacetam on the control of intractable status epilepticus. Methods from April 2014 to June 2015, the neurology department in our hospital. Seventy-two patients with refractory status epilepticus were included in this study. The patients were randomly divided into two groups: sodium valproate group and levoethoxetam group. Study participants of sodium valproate group treated with sodium valproate injection; The subjects of the study group were treated with levoethylacetam tablets UCB S.A. Belgium, import drug registration standard JX20070146). Results the total effective rate of sodium valproate group was 66.677.The total effective rate of levoethoxetam group was 62.5%. The total effective rate of the two drugs combined therapy was 91.67, the result was statistically significant (P 0.05). On the other hand, from the point of view of the time to control the status epilepticus. The control time of the combined group was relatively short, 41.64 mins, which was better than the effective time of the two groups. Conclusion the combined use of the two drugs. It has better effect and influence on the control of persistent state of refractory epilepsy.
【作者单位】：广东省江门市中心医院神经内科;
【分类号】：R742.1
【正文快照】： 难治性癫痫持续状态说的是癫痫症状的发生之后,到下一次癫痫症状发生前的时间差很短。换句话说,患者癫痫症状发作后还没有恢复到正常状态,又一次的症状再度发作,多次之后,便形成了这种持续性状态。在这个过程中,患者脑内神经元细胞的功能会不同程度的受到一定损伤,同时会出现

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