阜新农村地区高血压人群非高密度脂蛋白胆固醇水平与脑卒中发病的关系

发布时间：2018-01-10 04:03

本文关键词：阜新农村地区高血压人群非高密度脂蛋白胆固醇水平与脑卒中发病的关系　出处：《中国动脉硬化杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的了解阜新农村地区高血压人群的血脂分布状况,探讨高血压人群非高密度脂蛋白胆固醇(NonHDLC)水平和脑卒中发生的关系。方法 2004~2006年,于辽宁省阜新县农村地区采用多级整群抽样方法调查受访人群的血脂水平,2014年进行回访,最终纳入研究对象4 915人,按其Non-HDLC总体水平按四分位法分组,4组分别为:3.25 mmol/L组、3.25~mmol/L组、3.78~mmol/L组、4.33~mmol/L组,探讨Non-HDLC水平与脑卒中发病的关系。结果随着non-HDLC水平升高,总体脑卒中及缺血性脑卒中的发病率逐渐增加,而出血性脑卒中的发病率呈短暂上升后又呈一定下降。与3.25 mmol/L组比较,4.33~mmol/L组发生总体脑卒中[RR=1.39(1.11~1.75),P=0.004]及缺血性脑卒中[RR=1.75(1.32~2.32),P0.001]的风险明显升高;其他两组与3.25 mmol/L组比较,发生总体脑卒中及缺血性脑卒中的风险无统计学差异。而出血性脑卒中的相对危险度与non-HDLC水平无明显相关。结论 non-HDLC水平升高与高血压人群发生总体脑卒中及缺血性脑卒相关,而与出血性脑卒中无明显联系。应加强农村地区高血压人群的血脂水平监测和控制,以减少相关心脑血管疾病的发生。
[Abstract]:Objective to investigate the distribution of blood lipids in hypertensive population in rural areas of Fuxin. To investigate the relationship between the level of nonhigh density lipoprotein cholesterol (NonHDLCc) and the occurrence of stroke in hypertensive population. Methods from 2004 to 2006. The multistage cluster sampling method was used to investigate the blood lipid level in the rural areas of Fuxin County, Liaoning Province. In 2014, the blood lipid level of the population was visited back, and 4 915 subjects were included in the study. According to the total level of Non-HDLC, 4 groups were divided into 3. 25 mmol/L / L group and 3. 78 mmol / L group by quartile method. 4.33 mmol / L group to investigate the relationship between Non-HDLC level and stroke. Results the level of non-HDLC increased with the increase of non-HDLC level. The overall incidence of cerebral apoplexy and ischemic stroke increased gradually, but the incidence of hemorrhagic stroke increased briefly and then decreased to a certain extent, compared with 3.25 mmol/L group. 4.33 mmol / L group with total stroke. [RRN 1.39 ~ 1.11 ~ 1.75 ~ 1. 75 ~ 0. 004) and Ischemic Stroke. [The risk of RRN 1.75 ~ 1.32 ~ (2. 32) (P ~ (0.001)) increased significantly. The other two groups were compared with 3.25 mmol/L group. There was no significant difference in the risk of total stroke and ischemic stroke, but there was no significant correlation between the relative risk of hemorrhagic stroke and the level of non-HDLC. The increase of non-HDLC level was associated with overall stroke and ischemic stroke in hypertensive population. However, there is no obvious relationship with hemorrhagic stroke. The monitoring and control of blood lipid level in hypertensive population in rural areas should be strengthened in order to reduce the incidence of related cardiovascular and cerebrovascular diseases.
【作者单位】：中国医科大学附属盛京医院心内科;中国医科大学附属盛京医院临床流行病学教研室;中国医科大学附属第一医院心内科;
【基金】：辽宁省自然科学基金项目(2014021054)
【分类号】：R544.1;R743.3
【正文快照】： 血脂异常作为影响脑血管疾病的潜在因素,逐渐成为近年研究热点,由于受到既往临床指南及思维习惯影响,研究学者多采用低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDLC)作为高脂血症的参考指标,但由于存在大量LDLC水平正常而心血管事件风险较高的人群,因此LDLC的

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