美金刚治疗缺血性脑卒中后失语的疗效观察

发布时间：2018-01-14 10:35

本文关键词：美金刚治疗缺血性脑卒中后失语的疗效观察　出处：《重庆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：失语症(aphasia)即是由于获得性脑损害导致的语言功能受损甚至丧失的语言障碍综合征,可由多种疾病引起,成年人中最常见的是脑卒中。而脑卒中患者中有21%-38%伴有失语症,其中50%的患者语言障碍可持续至发病6个月以后。语言功能的受损使得患者的生活质量急剧下降,给患者及其整个家庭带来了巨大的痛苦和经济负担。目前国际上治疗失语症的方法多种多样,主要包括药物、语言训练、计算机辅助疗法、物理疗法等,但均未显现出特别优异的效果。近年来有研究发现N-甲基-D-天冬氨酸受体拮抗剂(盐酸美金刚)可促进脑卒中后失语症的恢复,且在语言理解及表达方面均有改善。但相关报道较少且多与其他方法联合治疗,而未研究美金刚单独治疗脑卒中后失语症的疗效。目的：观察美金刚对缺血性脑卒中后失语的疗效。材料与方法：选择2014年6月至2015年1月于重庆医科大学附属第一、第二医院入院的缺血性脑卒中后失语患者18例,均符合纳入、排除标准。根据患者意愿分为试验组与对照组,试验组患者8例,对照组10例。试验组患者服用美金刚至12周,对照组患者予以空白治疗。研究者分别在用药前、用药4周末、用药12周末使用中国康复研究中心汉语标准失语症检查表(CRRCAE)对两组患者进行语言测试,在各个观察点对组内及组间进行听理解、复述、自发语言、出声读及阅读理解5个方面语言功能的评价。结果：(1)两组患者在治疗4周末、12周末各个失语分项目评分均较各自治疗前有不同程度提高。(2)在治疗4周末、12周末,试验组患者在听理解、复述、自发语言、出声读、阅读理解5个方面均较对照组提高明显,且具有统计学意义。结论：(1)美金刚可能对缺血性脑卒中后失语具有改善作用。(2)本研究观察过程中未记录到不良反应,提示美金刚治疗缺血性脑卒中后失语具有良好的安全性及耐受性。
[Abstract]:Aphasia is a language disorder syndrome caused by acquired brain damage and even loss of language function, which can be caused by a variety of diseases. Stroke is most common in adults, and 21 to 38 percent of stroke patients are associated with aphasia. 50% of the patients had language disorders that lasted until 6 months after the onset of the disease. Impaired language function led to a sharp decline in the quality of life of the patients. It has brought great pain and economic burden to patients and their families. At present, there are a variety of methods for the treatment of aphasia in the world, including medicine, language training, computer-assisted therapy, physiotherapy and so on. In recent years, it has been found that N-methyl-Daspartic acid receptor antagonist (MJ) can promote the recovery of aphasia after stroke. And in language understanding and expression have improved, but the related reports are less and more combined with other methods of treatment. The effect of MJ on aphasia after stroke was not studied. Objective: to observe the efficacy of MJG in treating aphasia after ischemic stroke. Materials and methods:. First affiliated to Chongqing Medical University from June 2014 to January 2015. Eighteen patients with aphasia after ischemic stroke admitted to the second hospital were all in accordance with the inclusion and exclusion criteria. According to the wishes of the patients, they were divided into the experimental group and the control group, 8 cases in the experimental group. 10 cases in the control group. The patients in the experimental group were treated with the drug for 12 weeks, while the patients in the control group were given blank treatment. At the end of 12 weeks, CRRCAE was used to test the language of the two groups. Evaluation of language function in spontaneous speech, sound reading and reading comprehension. Results two groups of patients were treated for 4 weeks. At the end of 12 weeks, the scores of each aphasia item were improved in different degree than before treatment. (2) at the end of 4 weeks and 12 weeks after treatment, the patients in the trial group were listening and understanding, retelling, spontaneous language, and reading aloud. The five aspects of reading comprehension were significantly higher than those of the control group. Conclusion the effect of MJ on aphasia after ischemic stroke may be improved. 2) No adverse reactions were recorded in the course of this study. The results suggest that the treatment of aphasia after ischemic stroke is safe and tolerant.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R743.3

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