研究拉莫三嗪单药治疗小儿失神癫痫的临床效果
发布时间:2018-01-14 10:49
本文关键词:研究拉莫三嗪单药治疗小儿失神癫痫的临床效果 出处:《中国实用医药》2016年31期 论文类型:期刊论文
【摘要】:目的 探讨拉莫三嗪单药治疗小儿失神癫痫的临床效果。方法 80例小儿失神癫痫病患儿作为研究对象,依据不同治疗方法 分为观察组与对照组,各40例。对照组采用丙戊酸钠治疗,观察组采用拉莫三嗪单药治疗,对比两组临床疗效。结果 治疗后3个月,观察组患儿治疗总有效率为95.00%,明显高于对照组的77.50%,差异有统计学意义(P0.05)。观察组患儿在用药治疗期间出现3例不良反应症状,其中1例恶心、1例皮疹、1例记忆力衰退,不良反应发生率为7.50%;对照组患儿在用药治疗期间出现8例不良反应症状,其中2例恶心、2例皮疹、1例记忆力衰退、3例头痛,不良反应发生率20.00%;观察组不良反应发生率显著低于对照组,差异有统计学意义(P0.05)。结论 拉莫三嗦单药治疗小儿失神癫痫效果确切,短期内总有效率高,安全可靠,值得推广应用。
[Abstract]:Objective to explore the clinical effect of lamotrigine monotherapy in the treatment of childhood absence epilepsy. Methods 80 cases of childhood absence epilepsy patients as the research object, according to the different treatment methods were divided into observation group and control group, 40 cases in each group. The observation group was treated with sodium valproate, lamotrigine monotherapy, compared the clinical efficacy of two groups. Results after treatment 3 months, the total efficiency of the observation group was 95%, significantly higher than the control group 77.50%, the difference was statistically significant (P0.05). The symptoms of adverse reactions occurred in 3 cases of observation group during the treatment, including 1 cases of nausea, 1 cases of skin rash, 1 cases of memory loss, the incidence rate of adverse reaction was 7.50%; the symptoms of adverse reactions occurred in 8 patients in control group during the treatment, including 2 cases of nausea, 2 cases of skin rash, 1 cases of memory loss, headache in 3 cases, the incidence of adverse reactions was 20%; the observation group adverse reaction rate. The lower than the control group, the difference was statistically significant (P0.05). Conclusion three Suo monotherapy Rameau in childhood absence epilepsy is effective in the short term, the total effective rate is high, safe and reliable, it is worthy of popularization and application.
【作者单位】: 内蒙古自治区人民医院儿科;
【正文快照】: 小儿失神癫痫作为典型的神经系统异常特发性全身癫痫病症,其4~9岁阶段为该病症高发期。目前临床中治疗该病主要采用丙戊酸钠药物抗癫痫,其疗效对于原发性或初次失神症状者尚有一定疗效,不过复杂性失神疗效不足,并且有着一定的药物不良反应[1],为患者带来不小的痛苦。拉莫三嗪,
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