帕金森病患者血脂水平的变化及其临床相关性研究

发布时间：2018-01-16 06:09

本文关键词：帕金森病患者血脂水平的变化及其临床相关性研究　出处：《中华老年心脑血管病杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的观察帕金森病患者血脂水平变化及其临床相关性。方法选取帕金森病患者85例(帕金森病组),另选取健康体检者98例(对照组)。检测2组的血脂水平,并进行比较。结果帕金森病组HDL-C、TC、LDL-C、载脂蛋白B显著低于对照组[(1.35±0.37)mmol/L vs(1.46±0.33)mmol/L,P0.05;(4.33±0.90)mmol/L vs(4.94±0.98)mmol/L,P0.01;(2.50±0.80)mmol/L vs(3.08±0.88)mmol/L,P0.01;(1.54±0.31)μmol/L vs(1.75±0.40)μmol/L,P0.01]。帕金森病组男性TC、HDL-C明显低于女性,差异有统计学意义(P0.05)。帕金森病组TG水平与病程呈负相关(r=-0.230,P=0.034),其余各项血脂指标与病程及其严重程度均不相关(P0.05)。结论帕金森病患者血脂水平低于正常人,以男性帕金森病患者更为明显,低脂血症可能是帕金森病发病的潜在独立危险因素。
[Abstract]:Objective to observe the changes of serum lipids in patients with Parkinson's disease (PD) and its clinical correlation. Methods 85 patients with Parkinson's disease (PD) were selected. In addition, 98 healthy subjects (control group, control group) were selected to detect and compare the serum lipids levels in the two groups. Results HDL-Cn LDL-C and apolipoprotein B in Parkinson's disease group were significantly lower than those in the control group. [1. 35 卤0. 37 mmol / L vs(1.46 卤0. 33 mmol / L P0. 05; 4.33 卤0.90 mmol / L vs(4.94 卤0.98 mmol / L P 0.01; 2.50 卤0.80 mmol / L vs(3.08 卤0.88 mmol / L P 0.01; 1.54 卤0.31 渭 mol/L vs(1.75 卤0.40 渭 mol / L P0.01. HDL-C in male patients with Parkinson's disease was significantly lower than that in women. The difference was statistically significant (P 0.05). The level of TG in Parkinson's disease group was negatively correlated with the course of disease. Conclusion the level of blood lipid in Parkinson's disease patients is lower than that in normal people, especially in male patients with Parkinson's disease. Hypolipidemia may be a potential independent risk factor for Parkinson's disease.
【作者单位】：南京医科大学附属江苏盛泽医院神经内科;南京医科大学第一附属医院神经内科;
【基金】：江苏省自然科学基金面上项目(BK20141494)
【分类号】：R742.5
【正文快照】： 帕金森病是一种常见于中老年人群的慢性退行性疾病,主要表现为静止性震颤、肌强直、运动迟缓和姿势步态异常。据统计,目前我国的帕金森病患者已200万[1]。而且随着人口老龄化的加剧,其发病率还在逐年上升。目前,帕金森病已经成为危害中老年人生存及生活质量的重要疾病之一。

【相似文献】