缺血性脑血管病患者血清炎性标志物与颈动脉斑块相关性研究

发布时间：2018-01-19 16:20

本文关键词： 缺血性脑血管病血清炎性标志物颈动脉斑块稳定性　出处：《中国地方病防治杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探究缺血性脑血管病(ICVD)患者血清炎性标志物与颈动脉斑块相关性。方法用颈动脉超声检测64例ICVD患者颈内动脉中层厚度,依据检测结果分为无斑块组(22例)与斑块组(42例),并依据斑块性质再将斑块组分为不稳定斑块组(25例)与稳定斑块组(17例)。对各组既往病史、血清炎性标志物等进行比较,应用多因素logistic回归分析血清炎性标志物[肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、白介素-17(IL-17)、白介素-1β(IL-β)、基质金属蛋白酶-9(MMP-9)]和颈动脉斑块稳定性之间的相关性。结果斑块组的年龄、入院时舒张压、收缩压及TNF-α、hs-CRP、IL-17、IL-β、MMP-9等水平均高于无斑块组(P0.05);不稳定斑块组上述指标均明显高于稳定斑块组(P0.05);经多因素logistic回归分析得出IL-17、MMP-9是不稳定斑块发生的独立危险因素。结论 ICVD患者TNF-α、hs-CRP、IL-17、IL-β、MMP-9等水平和颈动脉斑块存在及斑块的稳定性密切相关,IL-17、MMP-9是斑块不稳定独立预测因素。
[Abstract]:Objective to investigate the correlation between serum inflammatory markers and carotid plaque in patients with ischemic cerebrovascular disease. Methods carotid artery ultrasound was used to detect the medial thickness of internal carotid artery in 64 patients with ICVD. According to the test results, 22 cases were divided into no plaque group (n = 22) and plaque group (n = 42). The plaque group was divided into unstable plaque group (n = 25) and stable plaque group (n = 17) according to the character of plaque. The history and serum inflammatory markers of each group were compared. Multivariate logistic regression analysis of serum inflammatory markers. [Tumor necrosis factor- 伪 (TNF- 伪), hypersensitive C-reactive protein (hs-CRPN), interleukin-17 (IL-17), interleukin-1 尾 (IL-1- 尾). Results the age, diastolic blood pressure, systolic blood pressure and TNF- 伪 hs-CRP in the plaque group. The levels of IL-17, IL- 尾 and MMP-9 were significantly higher than those in the plaque free group (P 0.05). The above indexes in unstable plaque group were significantly higher than those in stable plaque group (P 0.05). Multivariate logistic regression analysis showed that IL-17 MMP-9 was an independent risk factor for the occurrence of unstable plaque. Conclusion TNF- 伪 -hs-CRP is a risk factor in patients with ICVD. The levels of IL-17- 尾 -MMP-9 were closely related to the presence of carotid plaque and the stability of plaque. IL-17MMP 9 was an independent predictor of plaque instability.
【作者单位】：商丘医学高等专科学校内科护理教研室;武警后勤学院;
【基金】：商丘市2015年科技发展计划项目(项目编号:153058)
【分类号】：R743
【正文快照】： 目前,已有大量研究证实,动脉粥样硬化是导致脑梗死的重要病理基础之一,炎症因子所诱导的免疫炎性反应是引发进而导致脑梗死的重要原因[1]。动脉粥样硬化斑块中炎症细胞受刺激后会形成大量生物活性成分,抗炎与促炎活性成分间的平衡在动脉粥样硬化斑块的进展中发挥着关键作用,促

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