影响脑梗死患者阿司匹林抵抗的随访研究

发布时间：2018-01-26 14:53

本文关键词： 依从性阿司匹林抵抗脑梗死　出处：《中风与神经疾病杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的观察患者依从性与阿司匹林抵抗的关系,并探讨影响患者依从性的相关因素。方法纳入2014年-2015年于青岛大学附属医院出院的首发脑梗死患者451例,且住院时血栓弹力图(TEG)结果显示AA抑制率≥50%,随访12个月,终点事件为脑梗死复发或者死亡,复测患者AA抑制率结果,并运用Morisky-8服药依从性量表对患者进行服药依从性评估。结果共有429例患者纳入分析,AR患者为52例占12.12%,依从性差是AR发生的独立危险因素(P=0.027,OR=3.147,95%CI 1.004~9.834)。依从性较好比例只有35.89%,文化程度低、月收入低、医疗费用支付方式-自费、疾病了解少是依从性差的危险因素(P0.05)。结论依从性差是阿司匹林抵抗发生的独立危险因素;文化程度低、月收入低、医疗费用支付方式-自费、疾病了解少是依从性差的危险因素。
[Abstract]:Objective to observe the relationship between patient compliance and aspirin resistance. Methods 451 patients with initial cerebral infarction who were discharged from the affiliated Hospital of Qingdao University from 2014 to 2015 were included. The results of thromboelastography showed that the inhibition rate of AA was more than 50. After 12 months follow-up, the end point event was recurrence or death of cerebral infarction, and the inhibition rate of AA was measured again. The Morisky-8 compliance scale was used to evaluate the drug compliance of the patients. Results A total of #number1# patients were included in the analysis of 52 patients with AR, accounting for 12.12%. Poor compliance was the independent risk factor of AR. The ratio of compliance was only 35.89%. Low education level, low monthly income, medical expense payment method, low understanding of disease are the risk factors of poor compliance (P 0.05). Conclusion poor compliance is an independent risk factor for aspirin resistance. Low level of education, low monthly income, way of paying for medical expenses-self-expense and little understanding of disease are the risk factors of poor compliance.
【作者单位】：青岛大学附属医院神经内科;吉林大学第二医院心血管内科;
【基金】：青岛市民生科技计划项目(15-9-2-92-nsh)
【分类号】：R743.3
【正文快照】： 缺血性脑卒中具有较高的致残率和致死率,其二级预防越来越得到重视。阿司匹林作为脑梗死二级预防指南推荐药,应用越来越广泛[1]。部分患者即使常规服用阿司匹林仍继续经受缺血性心脑血管事件,称为阿司匹林抵抗(AR)[2]。研究显示AR在脑梗死的发生及复发中起重要作用[3]。AR发生

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