瑞舒伐他汀联合银杏叶提取物片对脑梗死合并糖尿病患者颈动脉粥样硬化斑块及炎症反应的影响

发布时间：2018-01-27 02:21

本文关键词： 瑞舒伐他汀银杏叶提取物片脑梗死糖尿病颈动脉粥样硬化斑块炎症反应　出处：《中国老年学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨瑞舒伐他汀联合银杏叶提取物片对脑梗死合并糖尿病患者颈动脉粥样硬化斑块及炎症反应的影响。方法 92例脑梗死合并糖尿病患者按照随机数字表法分为对照组和治疗组,每组46例,对照组采用瑞舒伐他汀钙片口服治疗,治疗组采用瑞舒伐他汀钙片和银杏叶提取物片口服治疗。治疗6个月后比较两组临床疗效、颈动脉粥样硬化斑块变化、白细胞介素6(IL)-6、IL-23及肿瘤坏死因子(TNF)-α炎症因子变化、血脂指标及不良反应发生情况。结果 6个月后治疗组的总有效率高于对照组(χ~2=5.844,P=0.016)。治疗组颈动脉内膜斑块面积、颈动脉内膜中膜厚度、易损斑块检出率显著低于对照组,IL-6、IL-23及TNF-α水平显著低于对照组(均P0.05)。治疗组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平显著低于对照组而高密度脂蛋白胆固醇(HDL-C)水平显著高于对照组(P0.05)。两组不良反应主要为胃肠道反应、恶心呕吐、头晕头痛、皮疹等,不良反应发生率比较差异无统计学意义(P0.05)。结论瑞舒伐他汀联合银杏叶提取物片治疗脑梗死合并糖尿病患者临床疗效明确,可降低颈动脉粥样硬化斑块,减轻炎症反应,改善血脂指标,安全性较好。
[Abstract]:Objective to investigate the effects of rosuvastatin combined with ginkgo biloba extract tablets on carotid atherosclerotic plaque and inflammation in patients with cerebral infarction and diabetes mellitus. 92 patients with cerebral infarction complicated with diabetes were divided into control group and treatment group according to random digital table method. 46 cases in each group, the control group was treated with rosuvastatin calcium tablets orally, the treatment group with rosuvastatin calcium tablets and ginkgo biloba extract tablets oral treatment. After 6 months of treatment, the clinical efficacy of the two groups was compared. The changes of carotid atherosclerotic plaque, IL-23 and TNF- 伪 inflammatory factor were observed. Results after 6 months, the total effective rate in the treatment group was higher than that in the control group (蠂 2 + 5.844). The area of carotid intimal plaque in the treatment group was higher than that in the control group. Carotid intima media thickness, vulnerable plaque detection rate was significantly lower than the control group. The levels of IL-23 and TNF- 伪 in the treatment group were significantly lower than those in the control group (P 0.05). The low density lipoprotein cholesterol (LDL-C) level was significantly lower than that of the control group (P 0.05), while the high density lipoprotein cholesterol (HDL-C) level was significantly higher than that in the control group (P 0.05). The main adverse reactions in the two groups were gastrointestinal reactions. Nausea, vomiting, dizziness, headache, rash, etc. There was no significant difference in the incidence of adverse reactions (P 0.05). Conclusion the clinical efficacy of Risuvastatin combined with Ginkgo biloba extract tablets in the treatment of cerebral infarction with diabetes mellitus is clear. It can reduce carotid atherosclerotic plaque, alleviate inflammation and improve blood lipid index.
【作者单位】：安阳市人民医院神经内科;
【分类号】：R587.1;R743.33
【正文快照】： 脑梗死合并糖尿病后,颈动脉会出现不同程度的动脉粥样硬化,加速脑梗死病情,增加治疗难度〔1〕。瑞舒伐他汀具有降脂、改善机体血脂、抗氧化、抑制细胞凋亡、改善内皮功能等多种药理作用〔2〕。银杏叶提取物片由银杏叶黄酮提取物制成,可改善血流量及缺氧状况,降低患者血脂水平,

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