脑梗死扩散峰度成像的时间进程分析及其与扩散张量成像的对比研究

发布时间：2018-01-28 20:11

本文关键词： 扩散峰度成像扩散张量成像磁共振成像脑梗死　出处：《中国医学影像技术》2017年05期 　论文类型：期刊论文

【摘要】：目的分析脑梗死患者扩散峰度成像(DKI)各参数随梗死时间的变化规律,并与扩散张量成像(DTI)进行对比。方法对95例脑梗死患者行DWI、DKI扫描,并根据脑梗死的时间分为5组:超急性期10例、急性期12例、亚急性期早期33例、亚急性期晚期20例、慢性期20例,获得DKI的相关参数图,测量病变区及对照区各参数值并计算其百分比变化率,分析各参数值随时间的演变规律。结果 DKI各参数值[平均扩散峰度(MK)、径向峰度(K⊥)、轴向峰度(K//)]在梗死后升高,急性期达到高峰,之后随时间延长逐渐下降;DTI各参数值[平均扩散系数(MD)、垂直扩散张量(D⊥)、轴向扩散张量(D//)]在梗死后降低,急性期达到最低,随时间延长逐渐升高。MK、K⊥、K//的百分比变化率较MD、D⊥、D//更高,且平行方向变化均大于垂直方向。结论 DKI评价脑梗死优于DTI,可更全面地分析脑梗死微观结构的改变。
[Abstract]:Objective to analyze the changes of DKI parameters with infarct time in patients with cerebral infarction and to compare them with diffusive Zhang Liang imaging. Methods 95 patients with cerebral infarction were treated with DWI. According to the time of cerebral infarction, DKI scan was divided into 5 groups: 10 cases of hyperacute phase, 12 cases of acute phase, 33 cases of early subacute phase, 20 cases of subacute stage and 20 cases of chronic phase. The relative parameter map of DKI was obtained, the parameter values of lesion area and control area were measured, the percentage change rate was calculated, and the evolution rule of each parameter value with time was analyzed. Results each parameter value of DKI was obtained. [Mean diffusion kurtosis, radial kurtosis, radial kurtosis, axial kurtosis (K / P)] increased after infarction, reached peak in acute phase, and then gradually decreased with time. [The average diffusion coefficient (MDR) was lower than that in the acute phase, and the mean diffusion coefficient was lower than that in the acute stage. The mean diffusion coefficient was higher than that in the vertical diffusivity (Zhang Liang / D, D / P) after infarction, and it increased gradually with the extension of time. The percentage change rate of K / / is higher than that of MDD / D /, and the change of parallel direction is larger than that of vertical direction. Conclusion DKI is superior to DTI in evaluating cerebral infarction. The microstructural changes of cerebral infarction can be analyzed more comprehensively.
【作者单位】：滨州医学院附属医院放射科;滨州医学院;西门子医疗系统有限公司北京分公司;
【分类号】：R445.2;R743.33
【正文快照】： 3.西门子医疗系统有限公司北京分公司,北京100102)目前,MR扩散加权成像是评价脑梗死的重要成像技术,在MR扩散加权成像基础上发展而来的扩散张量成像(diffusion tensor imaging,DTI)是以假定水分子扩散服从高斯分布为基础,而实际水分子扩散运动为非高斯分布,存在较大误差。扩散

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