长链非编码RNA在神经系统发育及神经性疾病中的作用

发布时间：2018-01-28 20:52

本文关键词： 长链非编码RNA 神经系统发育神经性疾病　出处：《中国生物化学与分子生物学报》2017年05期 　论文类型：期刊论文

【摘要】：长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度在200至数千个核苷酸序列,且不具有蛋白质编码潜能的非编码RNA。相较于研究较多的微小RNA(microRNA,miRNA)和干扰小RNA(small interfering,siRNA)等非编码小RNA,lncRNA的许多功能仍尚不清楚。但越来越多的研究发现,lncRNA可通过多种方式调控中枢神经系统发育,包括表观遗传组蛋白甲基化、转录辅因子调控、可变剪接调控等途经。而以上途经的异常均与多种人类重大疾病的发生密切相关,例如,阿尔兹海默症(Alzheimer’s disease,AD)、自闭症(autism spectrum disorder,ASD)、精神分裂症(schizophrenia,SZ)等。本文就lncRNA在表观遗传水平、转录水平、转录后水平和翻译水平上调控神经系统发育以及其在人类神经性疾病中的作用进行综述。
[Abstract]:Long chain noncoding RNA(long non-coding RNAs are a class of transcripts with lengths ranging from 200 to thousands of nucleotide sequences. And non-coding RNAs with no protein coding potential. Compared with the study of small RNA(microRNA. MiRNAs and interference small RNA(small interfering siRNAs, and other non-coding small RNA. Many functions of lncRNA are still unknown, but more and more studies have found that lncRNA can regulate the development of central nervous system in many ways, including epigenetic histone methylation. Transcriptional cofactor regulation, variable splicing regulation and other pathways. The above pathway abnormalities are closely related to the occurrence of a variety of major human diseases, such as. Alzheimer's disease (ADD), autism of autism (spectrum). In this paper, the epigenetic and transcriptional levels of lncRNA were studied. The posttranscriptional and transcriptional levels regulating the development of the nervous system and its role in human neurologic diseases are reviewed.
【作者单位】：南昌大学生命科学学院真核生物分子生物学研究室;
【基金】：国家自然科学基金项目(No.31660324) 江西省自然科学基金重大项目(No.20152ACB20008)资助~~
【分类号】：R741
【正文快照】： 31660324)and Jiangxi Natural Science Foundation(No.20152ACB20008)*Corresponding author Tel:18221012053;E-mail:1484498868@qq.com人类基因组计划研究表明,人类基因组中80%的基因具有生物学功能,其中仅约1.2%的基因组序列编码蛋白质,其余绝大部分基因组序列转录产生非

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