帕金森病患者24小时动态血压变化及其影响因素的临床研究

发布时间：2018-01-29 02:35

本文关键词： 帕金森病 h动态血压非运动症状自主神经功能障碍　出处：《中国临床神经科学》2014年02期 　论文类型：期刊论文

【摘要】：目的研究帕金森病(PD)患者动态血压变化特点及其相关的影响因素。方法采用无创性携带式动态血压监测仪行24 h动态血压监测,评估81例PD患者(PD组)和59名正常对照者(对照组)的动态血压变化节律,同时进行PD非运动症状问卷调查,探讨病理性血压节律的相关影响因素。结果①PD组患者血压节律倾向于非杓型血压;卧位血压升高的发生率较正常对照组高(P=0.001)。②PD组24 h平均血压、24 h平均收缩压、夜间平均血压、夜间平均收缩压、夜间平均舒张压均较对照组升高(P0.05);夜间平均动脉血压下降水平[MABP(%)]较对照组明显降低(P0.05)。③PD患者夜间血压变异系数(CV)与病程(P=0.019)、H-Y分级(P=0.047)、UPDRS评分(P=0.031)、心血管症状相关(P=0.016)、睡眠/疲劳(P=0.049)因素呈正相关。结论 PD患者血压节律偏向于非杓型血压,并广泛存在夜间血压升高现象,病理性血压节律可能是自主神经功能受损的潜在指标。
[Abstract]:Objective to study the characteristics of ambulatory blood pressure (ABBP) in patients with Parkinson's disease (PD) and its related influencing factors. Methods 24 h ambulatory blood pressure monitoring was performed with noninvasive portable ambulatory blood pressure monitor (ABPM). The rhythm of ambulatory blood pressure (ABBP) was evaluated in 81 PD patients with PD) and 59 normal controls (control group). Results 1the blood pressure rhythm of PD patients tended to be non-dipper blood pressure. The incidence of elevated blood pressure in the supine position was higher than that in the control group. The mean blood pressure in 24 h group was higher than that in the normal control group, and the mean systolic blood pressure at night and at night were higher than those in the control group. The mean diastolic blood pressure at night was higher than that in the control group (P 0.05). Nocturnal mean arterial blood pressure decrease. [Compared with the control group, the nocturnal blood pressure variation coefficient (CVV) and the course of the disease were significantly decreased in patients with P0.05U. 3PD and the course of disease was 0.019 ~ (H-Y) grade (P = 0.047). The UPDRS score was 0.031 and the cardiovascular symptoms were related to P0.016). Conclusion the blood pressure rhythm of PD patients is inclined to non-dipper blood pressure, and there is a widespread phenomenon of nocturnal blood pressure rising. Pathological blood pressure rhythm may be a potential indicator of autonomic nervous dysfunction.
【作者单位】：上海交通大学医学院附属新华医院神经内科;
【基金】：上海市级医院联合社区开展性病综合防治项目(编号:SHDC12012320)
【分类号】：R742.5
【正文快照】： 帕金森病(Parkinson’s disease,PD)是一种神经系统变性疾病,临床上以运动迟缓、震颤、强直表现为主。在过去的20年,PD非运动症状已被相关学者关注和研究。PD非运动症状对患者的生活质量影响很大[1],主要有便秘、抑郁、认知障碍、嗅觉障碍、快动眼相睡眠障碍等症状。其中自主

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