不同炎症反应在脑梗死与短暂性脑缺血发作患者中表达及意义研究

发布时间：2018-01-29 02:50

  本文关键词： 脑梗死 短暂性脑缺血发作 炎症因子　出处：《国际神经病学神经外科学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨不同炎症因子在脑梗死与短暂性脑缺血发作患者的表达情况。方法选取64例短暂性脑缺血发作患者(TIA组)、58例脑梗死患者(CI组)以及50例健康人员(NC组),分析并统计3组受试对象炎症因子表达情况。结果 CI组MMP-9(83.14±9.27)μg/L、NF-κB(36.88±6.27)%、IL-33(71.63±4.83)ng/m L及hs-CRP(12.57±1.29)mg/L,TIA组分别为(29.17±4.54)μg/L、NF-κB(31.20±5.97)%、IL-33(104.59±8.27)ng/m L及hs-CRP(6.23±1.04)mg/L,两组间比较差异具有统计学意义(P=0.026、P=0.032、P=0.025和P=0.009)。Logistic回归分析显示,TC、MMP-9、IL-33及hs-CRP为CI的独立危险因素。TC、hs-CRP为TIA的独立危险因素。MMP-9+IL-33+hs-CRP预测CI发生的AUC为0.859(95%CI:0.751~0.911),显著高于MMP-9(AUC为0.711,95%CI:0.649~0.824)、IL-33(AUC为0.698,95%CI:0.659~0.855)和hs-CRP(AUC为0.705,95%CI:0.671~0.848)的诊断效能(Z=9.267、11.553和10.234,均P=0.000)。结论脑梗死、短暂性脑缺血发作患者存在炎症因子表达差异,MMP-9、IL-33及hsCRP联合检测对CI具有较高的诊断价值。
[Abstract]:Objective to investigate the expression of different inflammatory factors in patients with cerebral infarction and transient ischemic attack. There were 58 patients with cerebral infarction (CI group) and 50 healthy persons (NC group). Results in CI group, MMP-9(83.14 卤9.27 渭 g / L NF- 魏 B was 36.88 卤6.27%. IL-33(71.63 卤4.83 ng / mL and hs-CRP(12.57 卤1.29 mg / L respectively. The TIA group was 29.17 卤4.54 渭 g / L of NF- 魏 B and 31.20 卤5.97 渭 g / L respectively. IL-33(104.59 卤8.27 ng / mL and hs-CRP(6.23 卤1.04 mg / L, the differences between the two groups were statistically significant (P < 0.026). Logistic regression analysis showed that the level of MMP-9 was significantly higher than that in the control group (P < 0. 032, P < 0. 032) and P < 0. 009. Logistic regression. IL-33 and hs-CRP were independent risk factors of CI. TC. Hs-CRP was an independent risk factor for TIA. MMP-9 IL-33 hs-CRP predicted that the AUC of CI was 0.859 (P < 0.05). 95 CI: 0.7511.0.911). Significantly higher than MMP-9(AUC was 0.71195 CI: 0.649% 0.824% IL-33 AUC was 0.698. The diagnostic efficacy of 95 CI: 0.659 / 0.855 and hs-CRP(AUC 0.705 / 95CI: 0.671 / 0.848). Conclusion there is a difference in the expression of inflammatory factors and MMP-9 in patients with cerebral infarction and transient ischemic attack. The combined detection of IL-33 and hsCRP has high diagnostic value for CI.
【作者单位】： 南通市第一人民医院神经内科;
【分类号】：R743.3
【正文快照】： 短暂性脑缺血发作(transient ischemic attack,TIA)主要指脑或者视觉功能急性丧失,症状持续1h,而在2 4 h内恢复,以往的研究认为该病为一种良性疾病,并未得到人们的重视[1],研究显示TIA有发展为CI的风险[2]。临床上已经证实了炎症因子参与了脑血管病的发展过程,但是不同炎症因，

本文编号：1472298