甲氨蝶呤鞘内注射治疗脑膜癌病疗效和安全性的临床观察

发布时间：2018-01-30 02:46

本文关键词： 脑膜癌病甲氨蝶呤鞘内注射安全性　出处：《中国肺癌杂志》2016年05期 　论文类型：期刊论文

【摘要】：背景与目的脑膜癌病是中枢神经系统转移瘤的一种少见类型。近年来,随着恶性肿瘤治疗疗效的提高,患者生存期延长,脑膜癌病的发病率逐年增加,目前尚缺乏有效的治疗手段。本研究旨在探讨鞘内注射甲氨蝶呤(methotrexate,MTX)治疗脑膜转移的疗效、安全性和预后。方法对27例脑膜转移患者的临床资料、脑脊液实验室检查进行回顾性分析,并分析鞘注化疗后的不良反应及预后。结果 27例脑膜转移患者接受鞘注化疗后,70.4%获得临床症状缓解,但脑脊液压力和脑脊液生化改变无统计学差异。55.6%患者无不适,25.9%出现下肢麻木、轻微疼痛,无严重不可逆的不良反应发生。本组患者中位生存期4个月。结论鞘内注射MTX可改善脑膜癌病患者临床症状,无严重不良反应发生。
[Abstract]:Background & objective meningeal carcinomatosis is a rare type of metastatic tumor in central nervous system. In recent years, with the improvement of therapeutic effect of malignant tumor, the survival time of patients is prolonged, and the incidence of meningeal carcinomatosis increases year by year. The purpose of this study was to investigate the efficacy of intrathecal injection of methotrexate methotrexate (MTX) in the treatment of meningeal metastasis. Methods the clinical data of 27 patients with meningeal metastasis and the laboratory examination of cerebrospinal fluid were retrospectively analyzed. The adverse reactions and prognosis of meningeal metastases were analyzed. Results 70.4% of the 27 patients with meningeal metastasis received sheath infusion chemotherapy and their clinical symptoms were relieved. But cerebrospinal fluid pressure and cerebrospinal fluid biochemical changes were not significantly different. 55.6% of the patients had no discomfort and 25.9% had lower extremity numbness and slight pain. There were no severe irreversible adverse reactions. The median survival time was 4 months. Conclusion Intrathecal injection of MTX can improve the clinical symptoms of meningeal cancer patients without serious adverse reactions.
【作者单位】：中国医学科学院肿瘤医院综合科;中国医学科学院肿瘤医院内科;中国医学科学院肿瘤医院放疗科;中国医学科学院肿瘤医院神经外科;
【分类号】：R739.45
【正文快照】： Efficacy and Security of Intrathecal with Methotrexate in the Treatment of MeningealCarcinomatosisXi WU1,Junling LI2,Jianping XIAO3,Boyan YANG1,Lei YU1,Xiaoming WU1,Jinghai WAN4,Haiyan XU1,Jianxin KONG41General Department;2Internal Department;3Radiothera

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