平均血小板体积与卵圆孔未闭并偏头痛患者视觉先兆的关系

发布时间：2018-01-31 22:38

本文关键词： 卵圆孔未闭偏头痛平均血小板体积视觉先兆　出处：《实用医学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的:探讨平均血小板体积(MPV)与卵圆孔未闭(PFO)合并偏头痛患者视觉先兆的关系。方法:收集南华大学第一医院神经内科2013年1月至2015年6月因先兆性偏头痛行经颅多普勒超声发泡试验检查结果为阳性患者120例作为研究对象,按随机数字表法分为手术组、氯吡格雷+手术组、氯吡格雷组、常规药物治疗组各30例。检测各组患者治疗前、后MPV,评估各组患者治疗后视觉先兆转归情况。结果:手术组、氯吡格雷+手术组、氯吡格雷组患者治疗前MPV分别为(10.98±1.41)fL、(10.94±1.40)fL、(10.88±1.41)fL,与常规药物治疗组患者治疗前MPV(10.91±1.46)fL比较差异无显著性(F=0.029,P=0.993)。手术组、氯吡格雷+手术组、氯吡格雷组患者治疗后MPV分别为(9.66±1.22)fL、(8.81±1.05)fL、(9.97±1.18)fL,与常规药物治疗组患者治疗后MPV(10.86±1.39)fL比较差异有显著性(P0.05)。与常规药物治疗组治疗比较,手术组、氯吡格雷+手术组、氯吡格雷组患者治疗后视觉先兆明显好转(P0.05)。结论:PFO合并偏头痛患者视觉先兆可能与MPV有关,下调PFO合并偏头痛患者MPV水平可改善患者的视觉先兆。
[Abstract]:Objective: to study the relationship between MPV (mean platelet volume) and PFOO in patients with patent foramen ovale. Relationship of visual aura in patients with migraine. Methods:. From January 2013 to June 2015, 120 patients with positive results of transcranial Doppler ultrasound foaming test due to aura migraine were collected from the Department of Neurology, first Hospital of South China University. The patients were randomly divided into three groups: operation group, clopidogrel group, clopidogrel group and routine drug treatment group. The MPV of each group was detected before and after treatment. Results: the MPV of operation group, clopidogrel group and clopidogrel group before treatment were 10.98 卤1.41fL. 10. 94 卤1. 40g / L + 10. 88 卤1. 41 fL. There was no significant difference in MPV(10.91 卤1.46 FL between the two groups before treatment. The operative group and clopidogrel group were treated with clopidogrel. The MPV of clopidogrel group after treatment was 9.66 卤1.22fL, 8.81 卤1.05fL, 9.97 卤1.18fL, respectively. There was a significant difference in MPV(10.86 卤1.39 FL between the two groups after treatment, compared with the conventional drug treatment group, the operation group. In clopidogrel group, visual aura improved significantly after treatment in clopidogrel group. Conclusion the visual aura may be related to MPV in patients with migraine. Lowering the level of MPV in PFO patients with migraine may improve the visual aura.
【作者单位】：南华大学附属第一医院神经内科;南华大学附属第一医院心身科;
【基金】：湖南省科技厅课题(编号:2015sk2046) 衡阳市科技局课题(编号:2015kj49)
【分类号】：R747.2
【正文快照】： 卵圆孔未闭(patent foramen ovale,PFO)患者体内平均血小板体积(mean platelet volume,MPV)较正常人偏大[1],行PFO封堵术后,MPV亦较术前变小[2]。因此,PFO可能与血小板活化有关。研究[3]表明,PFO封堵术后可改善PFO并有先兆偏头痛患者视觉先兆,抗血小板药物如氯吡格雷亦可改善P

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