毛细胞黏液样星形细胞瘤11例治疗与预后

发布时间：2018-02-01 02:39

本文关键词： 毛细胞黏液样星形细胞瘤生存状况最佳治疗模式　出处：《广东医学》2017年01期 　论文类型：期刊论文

【摘要】：目的分析毛细胞黏液样星形细胞瘤(PMA)患者的临床资料,探讨治疗模式与预后的关系。方法回顾性分析11例术后病理确诊为PMA的患者临床资料,其中6例术后行放化疗,分析患者生存状况,比较单纯手术组与放化疗组生存期(OS)。结果随访至2016年8月,两组患者中位随访时间为21(2~55)个月,中位OS为24个月,1年生存率为90.9%。两组OS比较差异无统计学意义(P=0.23),但对比术后3个月两组生活质量状况(KPS),放化疗组KPS明显优于单纯手术组(P=0.047)。结论 PMA发病率低、预后不良,手术切除是最主要治疗手段,放化疗的价值有待进一步研究。
[Abstract]:Objective to analyze the clinical data of patients with hair cell myxoid astrocytoma (PMA) and to explore the relationship between the treatment mode and prognosis. Methods the clinical data of 11 patients with PMA confirmed by pathology after operation were analyzed retrospectively. Six patients were treated with radiotherapy and chemotherapy after operation. The survival status of the patients was analyzed and the survival time was compared between the simple operation group and the radiotherapy and chemotherapy group. Results the results were followed up until August 2016. The median follow-up time was 21 卤55 months, the median OS was 24 months, and the 1-year survival rate was 90.9. There was no significant difference in OS between the two groups (P = 0.23). But three months after operation, the quality of life (QOL) of the two groups was compared. The KPS in the radiotherapy and chemotherapy group was significantly better than that in the simple operation group. Conclusion the incidence of PMA is low and the prognosis is poor. Surgical resection is the main treatment, the value of radiotherapy and chemotherapy needs further study.
【作者单位】：南方医科大学;广东三九脑科医院肿瘤科;广东三九脑科医院肿瘤综合治疗中心;南方医科大学南方医院放疗科;
【分类号】：R739.41
【正文快照】： ▲南方医科大学2014级在职在读硕士研究生,工作单位:广东三九脑科医院肿瘤科(广东广州510510)毛细胞黏液样星形细胞瘤(pilomyxoid astrocy-toma,PMA)是2007年WHO中枢神经系统肿瘤定义的一个新分类,是毛细胞星形细胞瘤的亚型,具有黏液样基质、围绕血管的多极细胞,没有Rosenthal

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