视神经脊髓炎谱系疾病患者中水通道蛋白4抗体与视神经损害的相关性

发布时间：2018-02-04 11:11

本文关键词： 视神经脊髓炎谱系疾病水通道蛋白抗体视神经损害脑脊液　出处：《中国医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨视神经脊髓炎谱系疾病(NMOSD)患者中水通道蛋白4(AQP4)抗体与视神经损害的关系及其临床意义。方法回顾性分析2010年1月至2015年10月我院经AQP4抗体检测确诊的53例NMOSD患者的临床与生化资料。根据是否有视神经损害分为视神经损害组与无视神经损害组,比较2组患者的临床与生化特征。根据AQP4抗体是否阳性将患者分为AQP4抗体阳性组与阴性组,比较2组视神经损害发生率。分析AQP4抗体与视神经损害的相关性。结果视神经损害组与无视神经损害组比较,患者性别、发病年龄、病程、括约肌功能障碍发生率、外周血白细胞计数、谷丙转氨酶值、脑脊液蛋白值、脑脊液免疫球蛋白指数及寡克隆带阳性率的差异无统计学意义(P0.05),复发次数、浅感觉减退发生率、血肌酐值及AQP4抗体阳性率的差异有统计学意义(P0.05)。AQP4抗体阳性组与AQP4抗体阴性组比较,视神经损害发生率的差异有统计学意义(F=4.93,P0.05)。AQP4抗体与视神经损害发生呈正相关(r=0.297,P0.05)。结论 NMOSD患者AQP4抗体阳性易出现视神经损害,两者的正相关关系有助于NMOSD患者视神经损害的早期预判及病情监测。
[Abstract]:Objective to investigate the neuromyelitisoptica spectrum disorder (NMOSD) patients with aquaporin 4 (AQP4) antibody and optic nerve damage and its clinical significance. Methods a retrospective analysis from January 2010 to October 2015 in our hospital diagnosed by detection of AQP4 antibody in 53 cases of NMOSD patients with clinical and biochemical data. According to whether there is damage to the optic nerve is seen nerve injury group and non nerve injury group, compared 2 groups of patients with clinical and biochemical characteristics. According to whether AQP4 antibody positive patients were divided into AQP4 positive group and negative group, compared 2 groups of optic nerve damage incidence. Correlation analysis of AQP4 anti body and optic nerve damage. The damage of optic nerve and optic nerve group damage group compared with gender, age of onset, course of disease, the incidence rate of sphincter dysfunction, peripheral blood leukocyte count, alanine aminotransferase values, cerebrospinal fluid protein, cerebrospinal fluid immunoglobulin index and oligo There was no statistically significant difference from the positive rate (P0.05), the recurrence rate of hypoesthesia occurred, there were statistically significant differences in serum creatinine and AQP4 antibody positive rate (P0.05).AQP4 antibody positive group and AQP4 negative group, the incidence of optic nerve damage and there was statistically significant difference (F=4.93, P0.05.AQP4) antibody and optic nerve damage were positively correlated (r=0.297, P0.05). Conclusion NMOSD positive AQP4 patients were prone to optic nerve damage is the correlation between the early prediction and monitoring can help NMOSD patients of optic nerve damage.

【作者单位】：第二军医大学附属长海医院神经内科;
【基金】：上海市优秀学术带头人计划(14XD1403400)
【分类号】：R744.52
【正文快照】： 随着水通道蛋白4(aquaporin-4,AQP4)的发现[1],其特异性抗体的表达在视神经脊髓炎、复发性视神经炎、纵向延伸横贯性脊髓炎及视神经脊髓型多发性硬化患者的脑脊液和血清中均可检测到[2]。据此特点,WINGERCHUK等[3]将视神经脊髓炎和上述其他疾病统称为视神经脊髓炎谱系疾病(n

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