颈动脉彩超结合hs-CRP检测在动脉粥样硬化脑梗死中的临床应用

发布时间：2018-02-04 12:55

本文关键词： 脑梗死不稳定斑块颈动脉彩超超敏C反应蛋白内中膜厚度　出处：《安徽医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：联合颈动脉彩超及超敏C反应蛋白(high-sensitive C-reactive protein, hs-CRP)检测，探讨两者在动脉粥样硬化脑梗死中的临床应用价值。方法：收集83例安徽省立医院神经内科急性动脉粥样硬化脑梗死患者（男性47例，女性36例）为实验组，50例我院同期健康体检者（男性28例，女性22例）为对照组。分别对脑梗死组与对照组进行颈动脉彩超及hs-CRP检测，详细记录两组颈动脉有无斑块、斑块性质和内-中膜厚度(Intima-media thickness, IMT)，并对其与脑梗死之间的关系进行比较和分析；对脑梗死患者进行NIHSS评分，比较分析不同程度神经功能障碍患者间IMT及hs-CRP水平的差异。结果： 1．脑梗死组斑块检出率、IMT及hs-CRP水平明显高于对照组，差异有统计学意义（P均0.05）； 2．不稳定斑块组hs-CRP、IMT水平及同侧脑梗死发生率均高于稳定斑块组，差异有统计学意义（P均0.05）； 3．hs-CRP水平与IMT成正相关（r=0.67，P0.05）。 4．hs-CRP水平与临床神经功能缺损评分成正相关（r=0.58，P0.05）。结论： 1．颈动脉粥样硬化不稳定斑块与脑梗死发生密切相关。 2．IMT与动脉粥样硬化及卒中风险密切相关，，超声测量颈动脉IMT增厚是一种可靠的评估动脉粥样硬化的无创性指标。 3．hs-CRP水平升高可增加颈动脉斑块不稳定性，并可反映神经功能损害程度。4．结合颈动脉彩超及hs-CRP检测有助于指导脑梗死的临床治疗和评估预后。
[Abstract]:Objective: Combined with carotid color Doppler ultrasound and high-sensitive C-reactive protein (hs-CRP), high-sensitive C-reactive protein (hs-CRP) was detected. To explore the clinical application value of both in atherosclerotic cerebral infarction. Methods: A total of 83 patients (47 males and 36 females) with acute atherosclerotic cerebral infarction (ACI) in Department of Neurology, Anhui Provincial Hospital, were selected as experimental group (n = 50, male 28). Carotid ultrasound and hs-CRP were performed in the cerebral infarction group and the control group respectively. The carotid plaques in both groups were recorded in detail. The characteristics of plaque and intima-media thickness. IMTT were compared and analyzed. The NIHSS scores of patients with cerebral infarction were evaluated and the differences of IMT and hs-CRP levels among patients with different degrees of neurological dysfunction were compared. Results: 1. The levels of IMT and hs-CRP in cerebral infarction group were significantly higher than those in control group (P < 0.05). 2. The level of hs-CRP IMT and the incidence of ipsilateral cerebral infarction in unstable plaque group were higher than those in stable plaque group (P < 0.05). 3. There was a positive correlation between hs-CRP level and IMT. 4. There was a positive correlation between hs-CRP level and clinical neurological impairment score (P 0.05). Conclusion: 1. The unstable plaque of carotid atherosclerosis is closely related to the occurrence of cerebral infarction. 2. IMT was closely associated with atherosclerosis and stroke risk. Measurement of carotid IMT thickening by ultrasound is a reliable noninvasive index for assessing atherosclerosis. 3. Increased levels of hs-CRP increased carotid plaque instability. Combined with carotid color ultrasound and hs-CRP, it is helpful to guide the clinical treatment and evaluate the prognosis of cerebral infarction.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.33;R543.4

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