缺血性脑卒中与血清叶酸的相关性研究

发布时间：2018-02-06 00:41

本文关键词： 叶酸缺血性脑卒中同型半胱氨酸　出处：《中国现代医学杂志》2016年22期 　论文类型：期刊论文

【摘要】：目的探讨血清叶酸水平与缺血性脑卒中的关系,检测和比较病例组和对照组血清叶酸水平。方法本研究是2013年7月-2013年12月在河南省人民医院进行的一项病例对照研究。60例缺血性脑卒中患者和60例健康受试者纳入本次研究。所有缺血性脑卒中患者,年龄均在20岁及以上,发病时间从24h~30d,经脑CT/头部MRI扫描证实。收集病例组和对照组血液样本,检测空腹血糖血清叶酸和血清同型半胱氨酸含量。结果病例组中45例(75%)为男性,15例(25%)为女性,年龄均值为(58.42±11.47)岁。对照组男性和女性分别为43例(71.7%)和17例(28.3%)。病例组和对照组血清叶酸水平分别为(6.26±4.06)和(8.07±4.70)。观察到病例组与对照组血清叶酸项之间的差异有统计学意义(P0.05)。本研究表明,在缺血性卒中的早期阶段,血清叶酸水平不足。结论低血清叶酸浓度与缺血性脑卒中风险增加存在显著性和独立性。
[Abstract]:Objective to investigate the relationship between serum folic acid level and ischemic stroke. Methods the study was conducted from July 2013 to December 2013 in Henan Provincial people's Hospital in a case-control study of 60 patients with ischemic stroke. Patients and 60 healthy subjects were included in this study. All patients with ischemic stroke. The age was 20 years old and above, the onset time was from 24 hours to 30 days, confirmed by CT / head MRI scan. Blood samples were collected from the case group and the control group. The contents of serum folic acid and homocysteine in fasting blood glucose were measured. Results in the case group, 45 cases (including 75%) were male and 15 cases (25%) were female. The mean age was 58.42 卤11.47 years old. The serum folic acid levels in the control group and the control group were 43 cases (71.7 cases) and 17 cases (28. 335%) respectively. The serum folic acid levels in the case group and the control group were respectively (. 6.26 卤4.06) and 8.07 卤4.70). The difference of serum folic acid between the case group and the control group was statistically significant (P 0.05). Conclusion low serum folic acid concentration and increased risk of ischemic stroke are significant and independent.
【作者单位】：河南省人民医院慢性病科;河南省人民医院神经内科;
【分类号】：R743.3

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