血塞通胶囊对老年缺血性脑血管病患者颈动脉粥样硬化软斑块及血液流变学的影响

发布时间：2018-02-12 07:14

本文关键词： 血塞通胶囊缺血性脑血管病血液流变学　出处：《中国老年学杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的探讨血塞通胶囊对老年缺血性脑血管病(ICD)患者颈动脉粥样硬化软斑块及血液流变学的影响。方法老年ICD患者106例,采用随机数字表法分为对照组(常规西药治疗)和观察组(常规西药治疗的基础上联合血塞通胶囊治疗)各53例。治疗前及治疗6个月后分别对两组进行彩超检查、血脂检查及血液流变学检查。观察并比较两组治疗过程中心血管事件的发生情况。结果治疗6个月后两组CAS软斑块的厚度、大小及颈动脉内膜中层厚度(IMT)均明显下降,且观察组低于对照组(P0.05)。治疗前与治疗6个月后,两组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)水平均无统计学差异(P0.05),治疗6个月后两组均较治疗前明显降低(P0.05)。治疗6个月后两组全血粘度(低切变率、高切变率)、血浆黏度、网织红细胞、血小板聚集率均明显下降(P0.05),且观察组明显低于对照组(均P0.05)。观察组心血管事件发生率明显低于对照组(P0.05)。结论血塞通胶囊与常规西药联合治疗老年ICD能有效改善患者的CAS软斑块和血液流变学指标,并具有较高的安全性。
[Abstract]:Objective to investigate the effect of Xuesaitong capsule on carotid atherosclerosis soft plaque and hemorheology in elderly patients with ischemic cerebrovascular disease. The patients were randomly divided into control group (conventional western medicine treatment) and observation group (53 cases treated with Xuesaitong capsule on the basis of routine western medicine treatment). The two groups were examined by color Doppler ultrasonography before and after 6 months of treatment. After 6 months of treatment, the thickness, size and intima-media thickness of CAS in the two groups were significantly decreased. And the observation group was lower than the control group (P 0.05). There was no significant difference in the levels of TGG, TC, LDL between the two groups. After 6 months of treatment, the whole blood viscosity (low shear rate, high shear rate, plasma viscosity) of the two groups was significantly lower than that of the pre-treatment group (low shear rate, high shear rate, plasma viscosity). Reticulocyte, The platelet aggregation rate decreased significantly in both groups, and the incidence of cardiovascular events in the observation group was significantly lower than that in the control group (P 0.05). Conclusion Xuesaitong capsule combined with conventional western medicine can effectively improve the incidence of ICD in the elderly. CAS soft plaque and hemorheology, And has high safety.
【作者单位】：郑州大学第五附属医院神经内五科;
【分类号】：R743.3

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