2型糖尿病老年患者血清维生素D水平与周围神经病变的关系

发布时间：2018-02-17 02:12

本文关键词： 型糖尿病糖尿病周围神经病变维生素D 老年人　出处：《上海交通大学学报(医学版)》2017年05期 　论文类型：期刊论文

【摘要】：目的·研究2型糖尿病老年患者维生素D水平与糖尿病周围神经病变(DPN)的关系,探讨其在DPN临床中的应用价值,为早期筛查及预防DPN提供依据。方法·选取2型糖尿病老年患者188例进行横断面研究,按照DPN诊断标准分为DPN组(100例)和无DPN组(88例)。收集所有患者临床资料,检测血清25羟维生素D_3[25(OH)D_3]水平,糖化血红蛋白(Hb A1c),血脂,肝、肾功能等。25(OH)D_3与各指标间进行相关性分析,并对DPN的危险因素行Logistic回归分析。结果·DPN患者血清25(OH)D_3水平中位数为34.95 nmol/L,显著低于无DPN患者(52.6 nmol/L)(P0.01)。25(OH)D_3水平与患者年龄、Hb A1c和空腹血糖呈负相关(r=-0.37,-0.53和-0.29,均P0.01)。多因素Logistic回归分析结果显示,血清25(OH)D_3水平降低是DPN发病的独立危险因素,血清25(OH)D_3处于下四分位数以下水平的糖尿病老年患者发生DPN的风险是上四分位数以上水平患者的15.50倍(OR=15.50,95%CI=2.00~119.62)。结论·血清25(OH)D_3水平降低可能增加DPN的患病风险,监测25(OH)D_3水平有助于早期发现DPN患者。
[Abstract]:Objective: to study the relationship between vitamin D level and diabetic peripheral neuropathy (DPN) in elderly patients with type 2 diabetes, and to explore the clinical value of vitamin D in DPN. Methods: a cross-sectional study was conducted in 188 elderly patients with type 2 diabetes mellitus. According to the diagnostic criteria of DPN, they were divided into DPN group (n = 100) and non-#en3# group (n = 88). Clinical data of all patients were collected. The levels of serum 25 hydroxyvitamin D3, HbA1cP, lipids, liver and kidney function were measured. Logistic regression analysis was used to analyze the risk factors of DPN. Results: the median of serum 25 OHHX D3 levels in DPN patients was 34.95 nmol / L, which was significantly lower than that in patients without DPN. There was a negative correlation between HbA1c and age and fasting blood glucose in patients with DPN, both P 0.01.Multivariate Logistic regression analysis showed that. The decrease of serum 25 OHH D3 level was an independent risk factor for the development of DPN. The risk of developing DPN in elderly patients with diabetes mellitus under the lower quartile was 15.50 times higher than that in patients above the upper quartile. Conclusion the decrease of serum 25 OHH D3 level may increase the risk of DPN. Monitoring 25 OHH D 3 levels is helpful for early detection of DPN patients.
【作者单位】：上海交通大学附属第一人民医院老年科;
【分类号】：R587.2;R745

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