经颅磁声刺激作用下耦合神经元的去同步研究

发布时间：2018-02-22 23:52

  本文关键词： 经颅磁声刺激 Hindmarsh-Rose模型 耦合神经元 去同步　出处：《中国生物医学工程学报》2017年04期 　论文类型：期刊论文

【摘要】：基于全同HR神经元的耦合系统模型,应用Simulink平台建立系统仿真模型,研究经颅磁声刺激对神经元同步活动的影响。通过分析不同参数下的经颅磁声刺激对神经元去同步的作用效果,发现适当参数下的外加磁声刺激可以有效减弱神经元的同步性。仿真结果表明:超声强度为0.7~0.8 W/cm~2时,去同步指数Q值变为0.041 7,耦合神经元出现去同步现象,从1.3~3.0 W/cm~2逐渐增大时,耦合神经元去同步指数Q值由0.041 7逐渐增大到0.625,神经元的放电模式发生了改变。调制超声波的占空比从40~70%变化时,去同步指数Q值变为0.041 7,耦合神经元的去同步对经颅磁声刺激具有敏感性;当调制超声波的周期从170~180 ms变化时,去同步指数Q值变为0.041 7,耦合神经元呈现去同步状态。研究结果揭示出经颅磁声刺激对耦合神经元去同步的作用规律,有助于探索经颅磁声刺激对神经精神类疾病治疗和康复的机理。
[Abstract]:Based on the coupled system model of all-in-one HR neurons, the system simulation model is established by using Simulink platform. To study the effect of transcranial magnetic sound stimulation (TMSS) on neuronal synchronization, the effects of transcranial magnetic acoustic stimulation (TMSS) on neuronal desynchronization under different parameters were analyzed. The results of simulation show that the intensity of ultrasound is 0.7 ~ 0.8 W / cm ~ 2:00, the de-synchronizing index Q value is 0.041 7, and the coupling neuron appears desynchronization phenomenon, which increases gradually from 1.3 ~ 3.0 W / cm ~ 2. The Q-value of the coupled neuron desynchronization index gradually increased from 0.041 7 to 0.625, and the firing mode of the neuron changed. When the duty cycle of the modulated ultrasonic wave changed from 40 ~ 70%, The Q value of desynchronization index changed to 0.0417, and the desynchronization of coupled neurons was sensitive to transcranial magnetoacoustic stimulation, and when the period of modulated ultrasound changed from 170 Ms to 180 Ms, The Q value of de-synchronizing index changed to 0.0417, and the coupling neurons showed desynchronization state. The results revealed the effect of transcranial magnetoacoustic stimulation on the de-synchronization of coupled neurons. It is helpful to explore the mechanism of transcranial magnetic sound stimulation in the treatment and rehabilitation of neuropsychiatric diseases.
【作者单位】： 燕山大学电气工程学院;北京师范大学认知神经科学和学习国家重点实验室;
【基金】：国家自然科学基金青年基金(61503321) 秦皇岛市科学技术研究与发展计划(F201601B042)
【分类号】：R741.044
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