情绪健康和生活质量对癫痫后轻微认知功能障碍的影响

发布时间：2018-02-23 03:03

本文关键词： 癫痫轻微认知功能障碍情绪健康生活质量　出处：《医学研究生学报》2017年04期 　论文类型：期刊论文

【摘要】：目的目前癫痫患者发生认知障碍的危险因素并不十分清楚,文中旨在评估成年癫痫患者临床特征、情绪健康及生活质量对轻微认知功能障碍(MCI)的影响。方法选择2015年10月至2016年10月南京军区南京总医院神经内科门诊就诊的成年癫痫患者109例,采用蒙特利尔认知评估量表(Mo CA)及简易精神状态量表(MMSE)评估患者的认知功能,汉密尔顿抑郁量表(HAMD-24)评价其情绪健康,生活质量评定量表-31(QOLIE-31)评定其生活质量;采用调查问卷收集患者的临床基线资料。结果 MCI患者67例(61.5%)。居住地区(OR=0.226,95%CI:0.082~0.627)是癫痫后MCI最有价值的预测因素,HAMD-24(OR=0.770,95%CI:0.644~0.921)、QOLIE-31总分(OR=0.712,95%CI:0.575~0.880)、生活质量(OR=1.070,95%CI:1.015~1.128)、自我认知功能(OR=1.120,95%CI:1.043~1.203)以及社会活动(OR=1.103,95%CI:1.035~1.175)是癫痫后MCI的危险因素。结论成人癫痫患者MCI的发生率偏高,临床工作中更应重视常规进行认知功能、情绪健康和生活质量的评估,可以有效延缓癫痫后认知障碍的发生和发展。
[Abstract]:Objective at present, the risk factors of cognitive impairment in epileptic patients are not very clear. The purpose of this paper is to evaluate the clinical characteristics of adult epileptic patients. Effects of emotional Health and quality of Life on mild Cognitive dysfunction (MCI) methods A total of 109 adult epilepsy patients were selected from the Department of Neurology, Nanjing General Hospital of Nanjing military region from October 2015 to October 2016. The cognitive function of the patients was evaluated with the Montreal Cognitive Assessment scale (MOCA) and the Mini-Mental State scale (MMSE). The patients' emotional health was evaluated with the Hamilton Depression scale (HAMD-24) and the quality of Life rating scale (-31QOLIE-31) was used to evaluate their quality of life (QOLIE-31). Results the clinical baseline data of patients with MCI were collected by questionnaire. Results 67 patients with MCI were 61.55.The area of residence was 0.22695 CI0.0820.627) the most valuable predictor of post-epileptic MCI was HAMD-24 OR-0.77095CI0.644 + 0.921OOLIE-31 total score OR0.71295CI05750.50.880.QOQIE-31 total score OR0.71295CI05750.880.OQIE-31, OR1.07095CIQ: 1.015151.128, OR1.12095CI1.0431.203) and social activities OR1.103CI1.0351.175. Conclusion the incidence of MCI in adult patients with epilepsy is higher than that in adults. In clinical work, we should pay more attention to the evaluation of cognitive function, emotional health and quality of life, which can effectively delay the occurrence and development of cognitive disorders after epilepsy.
【作者单位】：南京大学医学院附属金陵医院(南京军区南京总医院)神经内科;苏州市中西医结合医院脑病科;
【基金】：国家自然科学基金(81201078) 江苏省自然科学基金(BK20141373)
【分类号】：R742.1

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